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. 2014 Jul 1;8(3):37-43.

The effects of water pipe smoking on hematological parameters in rats

Ebrahim Miri-Moghaddam  1 , Ramazan Mirzaei  2 , Mohammad-Reza Arab  3 , Samaneh Kaikha  4
Affiliations

The effects of water pipe smoking on hematological parameters in rats

Ebrahim Miri-Moghaddam et al. Int J Hematol Oncol Stem Cell Res. .

Abstract

Objectives: This study aimed to investigate the effect of water-pipe (WP) smoking on hematological parameters of Wistar rats.

Methods: Thirty-five young male rats (200-250 g) were randomly assigned to five groups (n=7). The control group was exposed to room air and the experimental groups were exposed to WP smoking, using a special apparatus designed to have the ability to keep the rats for 40 minutes every day for 4, 8, 12 and 12 weeks; moreover, one of the two groups of 12 weeks of WP exposer had four following weeks of rest. Blood samples were collected to evaluate red blood cell count, hemoglobin, hematocrit, white blood cell and platelet counts.

Results: The results showed that RBC count, Hb and Hct parameters were significantly higher in WP smoking rats than the control group (P< 0.001). We found that WBC counts insignificantly increased (P < 0.39) but Plt counts insignificantly decreased (P < 0.13) in WP smoking rats compared with control group.

Conclusion: The findings may help to raise awareness of tobacco smokers about the potential toxicities of WP; likewise, the results can be used by physicians and public health officials in tobacco prevention programs.

Keywords: Health; Hematological parameters; Rat; Smoke; Water-Pipe.

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Conflict of interest statement

CONFLICT OF INTEREST

All authors declare no conflict of interest.

Figures

Figure 1
Figure 1
The effects of water-pipe smoking on red blood cell count (RBC) in different groups of rats exposed at different times. *: P < 0.05 vs. control group
Figure 2
Figure 2
The effects of water pipe smoking on hemoglobin (Hb) in different groups of rats exposed at different times. *: P < 0.05 vs. control group
Figure 3
Figure 3
The effects of water-pipe smoking on hematocrite (Hct) in different groups of rats exposed at different times. *: P < 0.05 vs. control group.
Figure 4
Figure 4
The effects of water-pipe smoking on white blood cell (WBC) parameter in different groups of rats exposed at different times.
Figure 5
Figure 5
The effects of water-pipe smoking on platelet (Plt) count parameter in different groups of rats exposed at different times.
See this image and copyright information in PMC

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