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. 2015:2015:832058.
doi: 10.1155/2015/832058. Epub 2015 Jan 6.

Association between Glucose Levels and Intraocular Pressure: Pre- and Postprandial Analysis in Diabetic and Nondiabetic Patients

Luis Guilherme Milesi Pimentel  1 , Carolina P B Gracitelli  1 , Leticia Sant'Ana Cardoso da Silva  1 , Aline Katia Siqueira Souza  1 , Tiago Santos Prata  2
Affiliations

Association between Glucose Levels and Intraocular Pressure: Pre- and Postprandial Analysis in Diabetic and Nondiabetic Patients

Luis Guilherme Milesi Pimentel et al. J Ophthalmol. 2015.

Abstract

The aim of this study was to evaluate the relationship between glucose levels and intraocular pressure (IOP) fluctuation in diabetic and nondiabetic patients. Seventeen nondiabetic and 20 diabetic subjects underwent a complete ophthalmic examination, capillary glucose testing, and applanation tonometry in two distinct situations: first, fasting for at least 8 hours and, second, postprandial measurements. Baseline glucose levels were higher in diabetic patients (P < 0.001). Postprandial IOP was significantly higher than baseline IOP in diabetic (P < 0.001) and nondiabetic patients (P = 0.006). Postprandial glucose levels were significantly higher than baseline measurements in both diabetic (P = 0.005) and nondiabetic patients (P = 0.015). There was a significant association between glucose levels variation and IOP change in both diabetic patients (R (2) = 0.540; P < 0.001) and nondiabetic individuals (R (2) = 0.291; P = 0.025). There is also a significant association between the baseline glucose levels and IOP change in diabetic group (R (2) = 0.445; P = 0.001). In a multivariable model, the magnitude of glucose level change remained significantly associated with IOP variation even including age, baseline IOP, ancestry, and gender as a confounding factor (P < 0.001). We concluded that there is a significant association between blood glucose levels and IOP variation, especially in diabetic patients.

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Figures

Figure 1
Figure 1
Box plots showing the distribution of average IOP in diabetic and nondiabetic groups in the two different times of measurements. Box represents median and interquartile range. Whiskers correspond to maximum and minimum 1.5 IQR.
Figure 2
Figure 2
Scatter plot showing the association between IOP variation and glucose levels variation in both groups.
Figure 3
Figure 3
Scatter plot depicting the relationship between IOP variations in the right and in the left eye (shaded area represents 95% confidence interval of the regression).
See this image and copyright information in PMC

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