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Review
. 2015 Jan 15:4:385.
doi: 10.3389/fonc.2014.00385. eCollection 2014.

CTLA-4 and PD-1 Pathway Blockade: Combinations in the Clinic

Margaret K Callahan  1 , Michael A Postow  1 , Jedd D Wolchok  2
Affiliations
Review

CTLA-4 and PD-1 Pathway Blockade: Combinations in the Clinic

Margaret K Callahan et al. Front Oncol. .

Abstract

Checkpoint blocking antibodies targeting regulatory molecules on T cells such as CTLA-4 and PD-1 have reinvigorated the field of cancer immunotherapy. These agents have demonstrated clinical activity across a variety of tumor types. Now that safety and clinical activity has been demonstrated in the monotherapy setting, the field is moving in the direction of testing novel combinations.

Keywords: CLTA-4; PD-1; immunotherapy; ipilimumab; nivolumab.

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References

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