doi: 10.1021/ol503541z.
Epub 2015 Feb 2.
Rh2(II)-catalyzed ester migration to afford 3H-indoles from trisubstituted styryl azides
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- PMID: 25642741
- DOI: 10.1021/ol503541z
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Rh2(II)-catalyzed ester migration to afford 3H-indoles from trisubstituted styryl azides
Org Lett.
.
Abstract
Rh2(II)-complexes trigger the formation of 3H-indoles from ortho-alkenyl substituted aryl azides. This reaction occurs through a 4π-electron-5-atom electrocyclization of the rhodium N-aryl nitrene followed by a [1,2]-migration to afford only 3H-indoles. The selectivity of the migration is dependent on the identity of the β-styryl substituent.
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