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Review
. 2015 Sep;9(3):369-75.
doi: 10.1007/s12105-015-0611-7. Epub 2015 Feb 3.

Hodgkin Lymphoma of the Nasopharynx: Case Report with Review of the Literature

Adepitan A Owosho  1 , Casey E Gooden, Alden G McBee
Affiliations
Review

Hodgkin Lymphoma of the Nasopharynx: Case Report with Review of the Literature

Adepitan A Owosho et al. Head Neck Pathol. 2015 Sep.

Abstract

We report an uncommon case and histopathologic work-up of Hodgkin lymphoma of the nasopharynx in a 49-year old female patient who presented with a 2-year complaint of bilateral nasal congestion. Histologic study revealed a lymphocyte rich subtype of classic Hodgkin lymphoma. Immunohistochemical analysis revealed CD15, CD30, OCT-2, BOB.1, and MUM-1 expression by the neoplastic cells and a lack of expression of CD45, CD20, CD3, EMA, and EBER. The review of the literature showed that Hodgkin lymphoma of the nasopharynx is rare, the most common reported subtype is the mixed cellularity, and Hodgkin lymphoma of the nasopharynx has a favorable prognosis.

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Figures

Fig. 1
Fig. 1
A non-contrast computed tomography scan of the paranasal sinuses shows a mass in the nasopharynx
Fig. 2
Fig. 2
Mass revealed Hodgkin lymphoma, lymphocyte rich subtype (H&E ×500). Black arrows point to Reed-Sternberg Cells and brown arrow points to a large mononucleated Hodgkin cell
Fig. 3
Fig. 3
Immunohistochemical panel a cytokeratin negative, b S100 negative, c HMB45 negative, d CD45 positive in small lymphoid cells but negative in large atypical cells, e CD20 positive in some small lymphoid cells but negative in large atypical cells, f CD3 positive in numerous small lymphoid cells forming rosettes around negative large atypical cells, g PAX5 weakly positive in large atypical cells, h CD15 positive in a typical membrane and paranuclear dot-like staining pattern in large atypical cells, i CD30 positive in a typical membrane and paranuclear dot-like staining pattern in large atypical cells, j MUM-1 positive in large atypical cells, k OCT-2 positive in large atypical cells, l BOB.1 weak to negative in some large atypical cells, m epithelial membrane antigen negative in small lymphoid and large atypical cells, and n EBER negative in small lymphoid and large atypical cells (original magnification ×1,000)
Fig. 4
Fig. 4
PET-CT scan. Arrows point to areas of fluorodeoxyglucose avidity in the nasopharynx and right level IIA lymph node
See this image and copyright information in PMC

Comment in

  • Primary Nasopharyngeal Hodgkin Lymphoma.
    Cencini E, Fabbri A, Lazzi S, Bocchia M. Cencini E, et al. Head Neck Pathol. 2015 Dec;9(4):536-7. doi: 10.1007/s12105-015-0637-x. Epub 2015 Jun 25. Head Neck Pathol. 2015. PMID: 26108528 Free PMC article. No abstract available.

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