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. 2015 Apr;39(4):686-94.
doi: 10.1038/ijo.2015.9. Epub 2015 Feb 3.

Maternal and neonatal outcomes for pregnancies before and after gastric bypass surgery

T D Adams  1 , A O Hammoud  2 , L E Davidson  3 , B Laferrère  4 , A Fraser  5 , J B Stanford  6 , M Hashibe  6 , J L J Greenwood  6 , J Kim  6 , D Taylor  7 , A J Watson  8 , K R Smith  9 , R McKinlay  10 , S C Simper  10 , S C Smith  10 , S C Hunt  11
Affiliations

Maternal and neonatal outcomes for pregnancies before and after gastric bypass surgery

T D Adams et al. Int J Obes (Lond). 2015 Apr.

Abstract

Background: Interaction between maternal obesity, intrauterine environment and adverse clinical outcomes of newborns has been described.

Methods: Using statewide birth certificate data, this retrospective, matched-control cohort study compared paired birth weights and complications of infants born to women before and after Roux-en-Y gastric bypass surgery (RYGB) and to matched obese non-operated women in several different groups. Women who had given birth to a child before and after RYGB (group 1; n=295 matches) and women with pregnancies after RYGB (group 2; n=764 matches) were matched to non-operated women based on age, body mass index (BMI) prior to both pregnancy and RYGB, mother's race, year of mother/s birth, date of infant births and birth order. In addition, birth weights of 13 143 live births before and/or after RYGB of their mothers (n=5819) were compared (group 3).

Results: Odds ratios (ORs) for having a large-for-gestational-age (LGA) neonate were significantly less after RYGB than for non-surgical mothers: ORs for groups 1 and 2 were 0.19 (0.08-0.38) and 0.33 (0.21-0.51), respectively. In contrast, ORs in all three groups for risk of having a small for gestational age (SGA) neonate were greater for RYGB mothers compared to non-surgical mothers (ORs were 2.16 (1.00-5.04); 2.16 (1.43-3.32); and 2.25 (1.89-2.69), respectively). Neonatal complications were not different for group 1 RYGB and non-surgical women for the first pregnancy following RYGB. Pregnancy-induced hypertension and gestational diabetes were significantly lower for the first pregnancy of mothers following RYGB compared to matched pregnancies of non-surgical mothers.

Conclusion: Women who had undergone RYGB not only had lower risk for having an LGA neonate compared to BMI-matched mothers, but also had significantly higher risk for delivering an SGA neonate following RYGB. RYGB women were less likely than non-operated women to have pregnancy-related hypertension and diabetes.

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Conflict of interest statement

All other authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Schematic description of groups 1, 2 and 3 used for study analysis. For groups 1 and 2, matching schemes are also depicted.
See this image and copyright information in PMC

References

    1. Grodstein F, Goldman MB, Cramer DW. Body mass index and ovulatory infertility. Epidemiology. 1994;5:247–250. - PubMed
    1. Lashen H, Fear K, Sturdee DW. Obesity is associated with increased risk of first trimester and recurrent miscarriage: matched case-control study. Hum Reprod. 2004;19:720–726. - PubMed
    1. Oveson P, Rasmussen S, Kesmodel U. Effect of prepregnancy maternal overweight and obesity on pregnancy outcome. Obstet Gynecol. 2011;118:305–312. - PubMed
    1. Kjaer MM, Nilas L. Pregnancy after bariatric surgery—a review of benefits and risks. Acta Obstet Gynecol Scand. 2012;92:264–271. - PubMed
    1. Weiss JL, Malone FD, Emig D, Ball RH, Nyberg DA, Comstock CH, et al. Obesity, obstetric complications and cesarean delivery rate—a population-based screening study. Am J Obstet Gynecol. 2004;190:1091–1097. - PubMed

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