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Randomized Controlled Trial
. 2015 Feb;145(2):284-90.
doi: 10.3945/jn.114.202010. Epub 2014 Dec 17.

Cholecalciferol supplementation does not influence β-cell function and insulin action in obese adolescents: a prospective double-blind randomized trial

Asma Javed  1 , Adrian Vella  2 , P Babu Balagopal  3 , Philip R Fischer  4 , Amy L Weaver  5 , Francesca Piccinini  6 , Chiara Dalla Man  7 , Claudio Cobelli  7 , Paula D Giesler  8 , Jeanette M Laugen  8 , Seema Kumar  9
Affiliations
Randomized Controlled Trial

Cholecalciferol supplementation does not influence β-cell function and insulin action in obese adolescents: a prospective double-blind randomized trial

Asma Javed et al. J Nutr. 2015 Feb.

Abstract

Background: There is increasing interest in the extraskeletal effects of vitamin D, particularly in the obese state with regard to the development of insulin resistance and diabetes.

Objective: The objective of the study was to determine the effect of 2 doses of cholecalciferol (vitamin D3) supplementation on insulin action (Si) and pancreatic β-cell function in obese adolescents.

Methods: We performed a 12-wk double-blind, randomized comparison of the effect of vitamin D3 supplementation on Si and β-cell function in obese Caucasian adolescents (body mass index > 95(th) percentile). The subjects were randomly assigned to receive either 400 IU/d (n = 25) or 2000 IU/d (n = 26) of vitamin D3. Each subject underwent a 7-sample 75 g oral glucose tolerance test, with glucose, insulin, and C-peptide measurements, to calculate Si and β-cell function as assessed by the disposition index (DI), with use of the oral minimal model before and after supplementation. A total of 51 subjects aged 15.0 ± 1.9 y were enrolled. Included for analysis at follow-up were a total of 46 subjects (20 male and 26 female adolescents), 23 in each group.

Results: Initial serum 25-hydroxyvitamin D [25(OH)D] was 24.0 ± 8.1 μg/L. There was no correlation between 25(OH)D concentrations and Si or DI. There was a modest but significant increase in 25(OH)D concentration in the 2000 IU/d group (3.1 ± 6.5 μg/L, P = 0.04) but not in the 400 IU/d group (P = 0.39). There was no change in Si or DI following vitamin D3 supplementation in either of the treatment groups (all P > 0.10).

Conclusions: The current study shows no effect from vitamin D3 supplementation, irrespective of its dose, on β-cell function or insulin action in obese nondiabetic adolescents with relatively good vitamin D status. Whether obese adolescents with vitamin D deficiency and impaired glucose metabolism would respond differently to vitamin D3 supplementation remains unclear and warrants further studies. This trial was registered at clinicaltrials.gov as NCT00858247.

Keywords: disposition index; insulin action; insulin secretion; obese adolescents; vitamin D supplementation.

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Figures

FIGURE 1
FIGURE 1
Consolidated Standards of Reporting Trials Diagram: Enrollment, random assignment, and follow-up of subjects. Vit, vitamin.
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