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. 2015;11(3):769-75.
doi: 10.1080/21645515.2015.1009339.

Decline in rotavirus hospitalizations following the first three years of vaccination in Castile-La Mancha, Spain

Olga Redondo  1 , Rosa Cano, Lorena Simón
Affiliations

Decline in rotavirus hospitalizations following the first three years of vaccination in Castile-La Mancha, Spain

Olga Redondo et al. Hum Vaccin Immunother. 2015.

Erratum in

  • Erratum.
    [No authors listed] [No authors listed] Hum Vaccin Immunother. 2015;11(12):2931-2. doi: 10.1080/21645515.2015.1122445. Hum Vaccin Immunother. 2015. PMID: 26697976 Free PMC article. No abstract available.

Abstract

Rotavirus is a major burden on the Spanish Healthcare System. Rotarix(®) and RotaTeq(®) were simultaneously commercialized in Spain by February, 2007. The objective is to analyze the incidence and seasonality of rotavirus hospitalizations (RH) in Castile-La Mancha (CLM), following the first 3 y of commercialization. A cross-sectional study of the hospital discharge registry's Minimum Basic Data Set (MBDS) in CLM between 2003 and 2009 was performed. We used the Poisson regression model to quantify the percentage of change in the rotavirus incidence rate (IR) for 2007-09 vs. 2003-05, adjusting for age, sex, and province. To analyze changes between epidemic seasons the chi-square test was used. The median IR in 2003-09 was 224.71 per 10(5) [interquartile range (IQR): 185.24-274.70], which represents 60% of hospital admissions due to infectious acute gastroenteritis. The median rate in 2007-09 decreased [incidence rate ratio (IRR): 0.86, 95% CI: 0.78-0.96], significantly in Toledo (IRR: 0.54, 95% CI: 0.39-0.75). An incipient decline at the beginning of the last cold season was observed, preceded by a significant decrease of 68% in the autumn season of 2009. Despite its limited coverage, the rotavirus vaccine may have contributed to decrease RH in CLM.

Keywords: AGE, Acute Gastroenteritis; ARGE, Acute Rotavirus Gastroenteritis; CLM, Castile-La Mancha; Children; IQR, Interquartile Range; IR, Incidence Rate; IRR, Incidence Rate Ratio; MBDS; MBDS, Minimum Basic Data Set; RH, rotavirus hospitalizations; Spain; hospitalizations; rotavirus; vaccines.

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Figures

Figure 1.
Figure 1.
Counting of hospital admissions by IAGE of typified and non-typified etiology. Source: MBDS. CLM, Spain. 2003–09.*
Figure 2.
Figure 2.
Distribution of triennial rates of acute rotavirus gastroenteritis by provinces. Children under 5 y of age. MBDS. CLM, Spain. 2003–05 and 2007–09. MBDS: Minimum Basic Data Set. CLM: Castile-La Mancha.
Figure 3.
Figure 3.
Seasonal distribution of the number of hospitalizations caused by rotavirus, Salmonella spp., Campylobacter jejuni and non-typified AGE. Children under 5 y of age. MBDS. CLM, Spain. 2003–09. AGE: acute gastroenteritis. MBDS: Minimum Basic Data Set. CLM: Castile-La Mancha.
Figure 4.
Figure 4.
Distribution of incidence rates of rotavirus hospital discharges by year groups. Children under 5 y of age. MBDS. CLM, Spain. 2003–09. MBDS: Minimum Basic Data Set. CLM: Castile-La Mancha. Y: year/s.
Figure 5.
Figure 5.
Distribution of rotavirus hospital discharge rates by year. Children under 5 y of age. MBDS. CLM, Spain. 2003–09. MBDS: Minimum Basic Data Set. CLM: Castile-La Mancha.
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