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Review
. 2015 Feb 3;131(5):503-12.
doi: 10.1161/CIRCULATIONAHA.114.001382.

Pharmacogenomics: personalizing pediatric heart transplantation

Sara L Van Driest  1 , Steven A Webber  2
Affiliations
Review

Pharmacogenomics: personalizing pediatric heart transplantation

Sara L Van Driest et al. Circulation. .
No abstract available

Keywords: drugs; pediatrics; pharmacogenetics; transplantation.

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Conflict of interest statement

Conflict of Interest Disclosures: None

Figures

Figure 1
Figure 1
Mechanisms of Pharmacogenomic Effect. Several types of genetic variation may lead to alterations in gene products. Pharmacogenes include those coding for a variety of cellular functions, and may alter drug response via pharmacokinetic (absorption, distribution, metabolism or excretion) or pharmacodynamic (direct drug effect) pathways.
Figure 2
Figure 2
Maintenance Immunosuppressant Use in Pediatric Heart Transplantation. Maintenance immunosuppression at 1 year (black bars) and 5 year (white bars) follow up in pediatric heart transplant recipients with visits from 2007 onwards. Percent of all patients receiving each drug is plotted on the Y axis. Sum across medications is greater than 100% due to concomitant use of two or more medications. MMF – mycophenolate mofetil; MPA – mycophenolic acid; mTOR – mammalian target of rapamycin. Based on published data.
Figure 3
Figure 3
Clinical Implementation of Pharmacogenomics for Pediatric Cardiac Transplantation. A) Example of clinical decision support implemented by the Vanderbilt University Medical Center Pharmacogenomic Resource for Enhanced Decisions in Care & Treatment. This warning is shown in the inpatient order system for individuals with one functional and one nonfunctional TPMT allele if an order is entered for a thiopurine drug. B) Result interpretation and prescribing guidance for CYP3A5*1 homozygosity, available at MyDrugGenome.org.
Figure 3
Figure 3
Clinical Implementation of Pharmacogenomics for Pediatric Cardiac Transplantation. A) Example of clinical decision support implemented by the Vanderbilt University Medical Center Pharmacogenomic Resource for Enhanced Decisions in Care & Treatment. This warning is shown in the inpatient order system for individuals with one functional and one nonfunctional TPMT allele if an order is entered for a thiopurine drug. B) Result interpretation and prescribing guidance for CYP3A5*1 homozygosity, available at MyDrugGenome.org.
See this image and copyright information in PMC

References

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