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Comment
. 2015 Jun 1;21(11):2421-3.
doi: 10.1158/1078-0432.CCR-14-2967. Epub 2015 Feb 2.

Can circulating tumor cells predict resistance in metastatic breast cancer?

Aju Mathew  1 , Adam M Brufsky  1 , Nancy E Davidson  2
Affiliations
Comment

Can circulating tumor cells predict resistance in metastatic breast cancer?

Aju Mathew et al. Clin Cancer Res. .

Abstract

Circulating tumor cell (CTC) enumeration provides prognostic but not predictive information for chemotherapy in metastatic breast cancer. Because CTC measurement is reproducible and allows molecular profiling, an assay to assess endocrine resistance was developed. Whether this CTC-based assay can be used to reliably select endocrine therapy must be tested.

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Conflict of interest statement

Disclosure of Potential Conflicts of Interest

No potential conflicts of interest were disclosed.

Figures

Figure 1
Figure 1
Circulating tumor cells (CTC) are malignant cells found in peripheral blood and their analysis could represent a real-time liquid biopsy. CTC count is prognostic for poor overall survival in metastatic breast cancer. The desired goal of CTC-based assays like CTC-ETI is to guide the selection of treatment of patients with metastatic breast cancer, so that breast cancer-related outcomes are improved.
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References

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