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Randomized Controlled Trial
. 2015 Mar 1;33(7):749-54.
doi: 10.1200/JCO.2014.57.2198. Epub 2015 Feb 2.

Meaning-centered group psychotherapy: an effective intervention for improving psychological well-being in patients with advanced cancer

William Breitbart  1 , Barry Rosenfeld  2 , Hayley Pessin  2 , Allison Applebaum  2 , Julia Kulikowski  2 , Wendy G Lichtenthal  2
Affiliations
Randomized Controlled Trial

Meaning-centered group psychotherapy: an effective intervention for improving psychological well-being in patients with advanced cancer

William Breitbart et al. J Clin Oncol. .

Abstract

Purpose: To test the efficacy of meaning-centered group psychotherapy (MCGP) to reduce psychological distress and improve spiritual well-being in patients with advanced or terminal cancer.

Patients and methods: Patients with advanced cancer (N = 253) were randomly assigned to manualized eight-session interventions of either MCGP or supportive group psychotherapy (SGP). Patients were assessed before and after completing the treatment and 2 months after treatment. The primary outcome measures were spiritual well-being and overall quality of life, with secondary outcome measures assessing depression, hopelessness, desire for hastened death, anxiety, and physical symptom distress.

Results: Hierarchical linear models that included a priori covariates and only participants who attended ≥ three sessions indicated a significant group × time interaction for most outcome variables. Specifically, patients receiving MCGP showed significantly greater improvement in spiritual well-being and quality of life and significantly greater reductions in depression, hopelessness, desire for hastened death, and physical symptom distress compared with those receiving SGP. No group differences were observed for changes in anxiety. Analyses that included all patients, regardless of whether they attended any treatment sessions (ie, intent-to-treat analyses), and no covariates still showed significant treatment effects (ie, greater benefit for patients receiving MCGP v SGP) for quality of life, depression, and hopelessness but not for other outcome variables.

Conclusion: This large randomized controlled study provides strong support for the efficacy of MCGP as a treatment for psychological and existential or spiritual distress in patients with advanced cancer.

Trial registration: ClinicalTrials.gov NCT00494910.

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Conflict of interest statement

Authors' disclosures of potential conflicts of interest are found in the article online at www.jco.org. Author contributions are found at the end of this article.

Figures

Fig 1.
Fig 1.
CONSORT diagram. MCGP, meaning-centered group psychotherapy; SGP, supportive group psychotherapy.
See this image and copyright information in PMC

Comment in

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