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Comment
. 2015 Feb 9;212(2):126.
doi: 10.1084/jem.2122insight1. Epub 2015 Feb 2.

Bee venom stirs up buzz in antigen presentation

Luc Van Kaer  1
Affiliations
Comment

Bee venom stirs up buzz in antigen presentation

Luc Van Kaer. J Exp Med. .
No abstract available

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Figures

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Insight from Luc Van Kaer
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Phospholipase A2 (PLA2) in bee venom is introduced into human skin and cleaves ubiquitous phospholipids into free fatty acids and lysophospholipids that function as neoantigens. These fatty acid neoantigens are now available for sampling by epidermal Langerhans cells, which load them onto CD1a proteins and present them at their surface to skin-resident CD1a-reactive T cells. These T cells produce cytokines such as IL-22 that contribute to the inflammatory response.
See this image and copyright information in PMC

Comment on

  • Bee venom processes human skin lipids for presentation by CD1a.
    Bourgeois EA, Subramaniam S, Cheng TY, De Jong A, Layre E, Ly D, Salimi M, Legaspi A, Modlin RL, Salio M, Cerundolo V, Moody DB, Ogg G. Bourgeois EA, et al. J Exp Med. 2015 Feb 9;212(2):149-63. doi: 10.1084/jem.20141505. Epub 2015 Jan 12. J Exp Med. 2015. PMID: 25584012 Free PMC article.

References

    1. Bourgeois, E.A., et al. . 2015. J. Exp. Med. 10.1084/jem.20141505. - DOI - PubMed