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Case Reports
. 2015 Feb 3;84(5):543-4.
doi: 10.1212/WNL.0000000000001203.

Eosinophilic CNS vasculitis can mimic demyelinating disease of the brain and spinal cord

Raphael Schneider  1 , Jenny P Tsai  2 , David G Munoz  2 , Daniel H Selchen  2
Affiliations
Case Reports

Eosinophilic CNS vasculitis can mimic demyelinating disease of the brain and spinal cord

Raphael Schneider et al. Neurology. .
No abstract available

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Figures

Figure 1
Figure 1. MRI of the brain and spinal cord
Juxtacortical and periventricular (A, C, E) T2 hyperintensities with varying degrees of enhancement (B, D, F). Note T2 hyperintensity at T7-T10 with edema (G, arrows) and gadolinium enhancement (H, arrows).
Figure 2
Figure 2. Brain biopsy
(A, hematoxylin & eosin) Vasculitis (black arrow), infarcts (white arrow), inset with macrophages. Transmural infiltration by macrophages (B, CD163), lymphocytes, polymorphonuclear leukocytes (C, trichrome), and numerous eosinophils (D, arrows, hematoxylin & eosin), destroying the vessel wall (E, arrow, smooth muscle myosin). (F, hematoxylin phloxine saffron; G, trichrome) Chronic, scarring phase. (H) Minimal perivascular myelin loss.
See this image and copyright information in PMC

References

    1. Sommerville RB, Noble JM, Vonsattel JP, Delapaz R, Wright CB. Eosinophilic vasculitis in an isolated central nervous system distribution. BMJ Case Rep 2009;2009. - PMC - PubMed
    1. Na SJ, Lee KO, Ko JH. Eosinophilic vasculitis of the spinal cord associated with Churg-Strauss syndrome. J Neurol Sci 2010;295:107–109. - PubMed

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