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Clinical Trial
. 2015 Feb 2;20(2):2492-509.
doi: 10.3390/molecules20022492.

Production and characterization of cosmetic nanoemulsions containing Opuntia ficus-indica (L.) mill extract as moisturizing agent

Renato Cesar de Azevedo Ribeiro  1 , Stella Maria de Andrade Gomes Barreto  2 , Elissa Aarantes Ostrosky  3 , Pedro Alves da Rocha-Filho  4 , Lourena Mafra Veríssimo  5 , Márcio Ferrari  6
Affiliations
Clinical Trial

Production and characterization of cosmetic nanoemulsions containing Opuntia ficus-indica (L.) mill extract as moisturizing agent

Renato Cesar de Azevedo Ribeiro et al. Molecules. .

Abstract

This study aimed to produce and characterize an oil in water (O/W) nanoemulsion containing Opuntia ficus-indica (L.) Mill hydroglycolic extract, as well as evaluate its preliminary and accelerated thermal stability and moisturizing efficacy. The formulations containing 0.5% of xanthan gum (FX) and 0.5% of xanthan gum and 1% of Opuntia ficus-indica MILL extract (FXE) were white, homogeneus and fluid in aspect. Both formulations were stable during preliminary and accelerated stability tests. FX and FXE presented a pH compatible to skin pH (4.5-6.0); droplet size varying from 92.2 to 233.6 nm; a polydispersion index (PDI) around 0.200 and a zeta potential from -26.71 to -47.01 mV. FXE was able to increase the water content of the stratum corneum for 5 h after application on the forearm. The O/W nanoemulsions containing 1% of Opuntia ficus-indica (L.) Mill extract presented suitable stability for at least for 60 days. Besides, this formulation was able to increase the water content of stratum corneum, showing its moisturizing efficacy.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Droplet size graphic of accelerated stability tests of nanoemulsions with and without Opuntia ficus-indica (L.) Mill extract.
Figure 2
Figure 2
Dynamic Light Scattering (DLS) size distribution of stable samples (FX and FXE) after 60 days.
Figure 3
Figure 3
Zeta potential graphic of accelerated stability tests of nanoemulsions with and without Opuntia ficus-indica (L.) Mill extract.
Figure 4
Figure 4
Water content values of the stratum corneum measured by Corneometer® CM 825 before and after 1, 2, 3, 4 and 5 h application of formulations.
See this image and copyright information in PMC

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