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Review
. 2016 Feb;46(2):139-48.
doi: 10.1007/s00595-015-1120-8. Epub 2015 Feb 5.

Trials of vaccines for pancreatic ductal adenocarcinoma: Is there any hope of an improved prognosis?

Toru Mizuguchi  1   2 , Toshihiko Torigoe  3 , Fukino Satomi  4 , Hiroaki Shima  4 , Goro Kutomi  4 , Shigenori Ota  4 , Masayuki Ishii  4 , Hiroshi Hayashi  5 , Sumiyo Asakura  6 , Yoshihiko Hirohashi  3 , Makoto Meguro  4 , Yasutoshi Kimura  4 , Toshihiko Nishidate  4 , Kenji Okita  4 , Masaho Ishino  7 , Atsushi Miyamoto  8 , Masamitsu Hatakenaka  9 , Noriyuki Sato  3 , Koichi Hirata  4
Affiliations
Review

Trials of vaccines for pancreatic ductal adenocarcinoma: Is there any hope of an improved prognosis?

Toru Mizuguchi et al. Surg Today. 2016 Feb.

Abstract

Pancreatic tumors are chemoresistant and malignant, and there are very few therapeutic options for pancreatic cancer, as the disease is normally diagnosed at an advanced stage. Although attempts have been made to develop vaccine therapies for pancreatic cancer for a couple of decades, none of the resultant protocols or regimens have succeeded in improving the clinical outcomes of patients. We herein review vaccines tested within the past few years, including peptide, biological and multiple vaccines, and describe the three sets of criteria used to evaluate the therapeutic activity of vaccines in solid tumors.

Keywords: Immunomodulation; Pancreatic cancer; Vaccine.

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