Prevalence of hyposalivation in patients with systemic lupus erythematosus in a brazilian subpopulation

Cristhiane Almeida Leite¹, Marcial Francis Galera², Mariano Martínez Espinosa³, Paulo Ricardo Teles de Lima⁴, Vander Fernandes⁵, Álvaro Henrique Borges⁶, Eliane Pedra Dias⁷

Affiliations

¹ Department of Oral Pathology, University of Cuiabá, Avenida Manoel José de Arruda 3.100 Jardim Europa, 78065-900 Cuiabá, MT, Brazil ; Department of Pathology, Federal Fluminense University, Rua Marquês do Paraná 303, No. 4 Andar do Prédio Principal, Sala 1, 24.033-900 Niterói, RJ, Brazil.
² Department of Pediatrics, School of Medicine, Federal University of Mato Grosso, Avenida Fernando Corrêa da Costa 2367, Boa Esperança, 78060-900 Cuiabá, MT, Brazil.
³ Department of Statistics, Institute of Exact Sciences, Federal University of Mato Grosso, Avenida Fernando Corrêa da Costa 2367, Boa Esperança, 78060-900 Cuiabá, MT, Brazil.
⁴ School of Dentistry, University of Cuiabá, Brazil Avenida Manoel José de Arruda 3.100, Jardim Europa, 78065-900 Cuiabá, MT, Brazil.
⁵ Department of Rheumatology, University of Cuiabá, Avenida Manoel José de Arruda 3.100, Jardim Europa, 78065-900 Cuiabá, MT, Brazil.
⁶ Faculty of Dentistry, University of Cuiabá, Avenida Manoel José de Arruda 3.100, Jardim Europa, 78065-900 Cuiabá, MT, Brazil.
⁷ Department of Pathology, Federal Fluminense University, Rua Marquês do Paraná 303, No. 4 Andar do Prédio Principal, Sala 1, 24.033-900 Niterói, RJ, Brazil.

PMID: 25649631
PMCID: PMC4305611
DOI: 10.1155/2015/730285

Prevalence of hyposalivation in patients with systemic lupus erythematosus in a brazilian subpopulation

Cristhiane Almeida Leite et al. Int J Rheumatol. 2015.

. 2015:2015:730285.

doi: 10.1155/2015/730285. Epub 2015 Jan 11.

Authors

Cristhiane Almeida Leite¹, Marcial Francis Galera², Mariano Martínez Espinosa³, Paulo Ricardo Teles de Lima⁴, Vander Fernandes⁵, Álvaro Henrique Borges⁶, Eliane Pedra Dias⁷

Affiliations

¹ Department of Oral Pathology, University of Cuiabá, Avenida Manoel José de Arruda 3.100 Jardim Europa, 78065-900 Cuiabá, MT, Brazil ; Department of Pathology, Federal Fluminense University, Rua Marquês do Paraná 303, No. 4 Andar do Prédio Principal, Sala 1, 24.033-900 Niterói, RJ, Brazil.
² Department of Pediatrics, School of Medicine, Federal University of Mato Grosso, Avenida Fernando Corrêa da Costa 2367, Boa Esperança, 78060-900 Cuiabá, MT, Brazil.
³ Department of Statistics, Institute of Exact Sciences, Federal University of Mato Grosso, Avenida Fernando Corrêa da Costa 2367, Boa Esperança, 78060-900 Cuiabá, MT, Brazil.
⁴ School of Dentistry, University of Cuiabá, Brazil Avenida Manoel José de Arruda 3.100, Jardim Europa, 78065-900 Cuiabá, MT, Brazil.
⁵ Department of Rheumatology, University of Cuiabá, Avenida Manoel José de Arruda 3.100, Jardim Europa, 78065-900 Cuiabá, MT, Brazil.
⁶ Faculty of Dentistry, University of Cuiabá, Avenida Manoel José de Arruda 3.100, Jardim Europa, 78065-900 Cuiabá, MT, Brazil.
⁷ Department of Pathology, Federal Fluminense University, Rua Marquês do Paraná 303, No. 4 Andar do Prédio Principal, Sala 1, 24.033-900 Niterói, RJ, Brazil.

PMID: 25649631
PMCID: PMC4305611
DOI: 10.1155/2015/730285

Abstract

Background. Systemic lupus erythematosus (SLE) is a chronic inflammatory, multisystem, and autoimmune disease. Objective. The aim of this study was to describe the prevalence of hyposalivation in SLE patients and evaluate factors associated. Methods. This is a cross-sectional study developed at the Cuiaba University General Hospital (UNIC-HGU), Mato Grosso, Brazil. The study population consisted of female SLE patients treated at this hospital from 06/2010 to 12/2012. Unstimulated salivary flow rates (SFRs) were measured. Descriptive and inferential analyses were performed in all cases using a significance level P < 0.05. Results. The results showed that 79% of patients with systemic lupus erythematosus suffered from hyposalivation and that the disease activity and age in years were the factors that resulted in statistically significant differences. Conclusion. The activity of the disease, age >27 years, and the drugs used were factors associated with hyposalivation, resulting in a statistically significant decrease in saliva production.

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Figures

**Figure 1**
(a) Box plots comparing the amount of saliva by age in years. (b) Box plots comparing the amount of saliva by age in years.

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Prevalence of hyposalivation in patients with systemic lupus erythematosus in a brazilian subpopulation

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Prevalence of hyposalivation in patients with systemic lupus erythematosus in a brazilian subpopulation

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