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Randomized Controlled Trial
. 2015 Jan-Mar;8(1):19-26.
doi: 10.1016/j.optom.2014.03.002. Epub 2014 Apr 24.

Overnight corneal swelling with high and low powered silicone hydrogel lenses

Amir M Moezzi  1 , Desmond Fonn  2 , Jalaiah Varikooty  2 , Trefford L Simpson  2
Affiliations
Randomized Controlled Trial

Overnight corneal swelling with high and low powered silicone hydrogel lenses

Amir M Moezzi et al. J Optom. 2015 Jan-Mar.

Abstract
in English, Spanish

Purpose: To compare central corneal swelling after eight hours of sleep in eyes wearing four different silicone hydrogel lenses with three different powers.

Methods: Twenty-nine neophyte subjects wore lotrafilcon A (Dk, 140), balafilcon A (Dk, 91), galyfilcon A (Dk, 60) and senofilcon A (Dk, 103) lenses in powers -3.00, -10.00 and +6.00 D on separate nights, in random order, and on one eye only. The contra-lateral eye (no lens) served as the control. Central corneal thickness was measured using a digital optical pachometer before lens insertion and immediately after lens removal on waking.

Results: For the +6.00 D and -10.00 D, lotrafilcon A induced the least swelling and galyfilcon A the most. The +6.00 D power, averaged across lens materials, induced significantly greater central swelling than the -10.00 and -3.00 D (Re-ANOVA, p<0.001), (7.7±2.9% vs. 6.8±2.8% and 6.5±2.5% respectively) but there was no difference between -10.00 and -3.00 D. Averaged for power, lotrafilcon A induced the least (6.2±2.8%) and galyfilcon A the most (7.6±3.0%) swelling at the center (Re-ANOVA, p<0.001). Central corneal swelling with +6.00 D was significantly greater than -10.00 D lens power despite similar levels of average lens transmissibility of these two lens powers.

Conclusions: The differences in corneal swelling of the lens wearing eyes are consistent with the differences in oxygen transmission of the silicone hydrogel lenses. In silicone hydrogel lenses central corneal swelling is mainly driven by central lens oxygen transmissibility.

Objetivo: Comparar el edema central de la córnea tras ocho horas de sueño, en ojos con cuatro lentes diferentes de hidrogel de silicona de tres potencias diferentes.

Métodos: Veintinueve pacientes no usuarios de lentes de contacto llevaron lentes de lotrafilcon A (Dk, 140), balafilcon A (Dk, 91), galyfilcon A (Dk, 60) y senofilcon A (Dk, 103) con potencias de −3,00, −10,00 y +6.00 D durante noches diferentes, en orden aleatorio, y en un solo ojo. El ojo contra-lateral (sin lente) se utilizó como control. El espesor central de la córnea se midió utilizando un paquímetro óptico digital antes de la inserción e inmediatamente tras la retirada de la lente al despertar.

Resultados: Para +6,00 D y −10,00 D, lotrafilcon A produjo el menor edema, comparado con galyfilcon A. La potencia +6,00 D, promediada en los materiales de las lentes, produjo un edema central considerablemente mayor que las potencias −10,00 y −3,00 D (Re-ANOVA, p < 0,001), (7,7 ± 2,9% frente a 6,8 ± 2,8% y 6,5 ± 2,5% respectivamente), pero no existió diferencia entre −10,00 y −3,00 D. Promediando las potencias para cada lente, lotrafilcon A produjo el menor edema en el centro (6,2 ± 2,8%) y galyfilcon A la mayor (7,6 ± 3,0%) (Re-ANOVA, p < 0,001). El edema corneal central con +6,00 D fue considerablemente superior que la de la potencia de lente −10,00 D, a pesar de los niveles similares de transmisibilidad media de la lente de estas dos potencias.

Conclusiones: Las diferencias en cuanto a edema de la córnea de los ojos portadores de lentes son consistentes con las diferencias en cuanto a transmisión del oxígeno de las lentes de hidrogel de silicona. En las lentes de hidrogel de silicona, el edema corneal central es principalmente debido a la transmisibilidad del oxígeno central de la lente.

Keywords: Corneal swelling; Corneal thickness; Edema corneal; Optical pachometry; Oxygen transmissibility; Silicone hydrogel lenses; espesor de la córnea; lentes de hidrogel de silicona; paquimetría óptica; transmisibilidad del oxígeno.

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Figures

Figure 1
Figure 1
Overnight central corneal swelling for each lens power (vertical bars denote 0.95 confidence intervals, the significantly different pairs are indicated by brackets and asterisks).
Figure 2
Figure 2
Overnight central corneal swelling (lens vs. control) (vertical bars denote 0.95 confidence intervals).
Figure 3
Figure 3
Overnight central corneal swelling by lens power (lens vs. control) (vertical bars denote 0.95 confidence intervals).
See this image and copyright information in PMC

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