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. 2015 Mar;90(3):339-45.
doi: 10.1016/j.mayocp.2014.12.016. Epub 2015 Jan 31.

Effect of physical activity assessment on prognostication for peripheral artery disease and mortality

Peter Chang  1 , Kevin T Nead  2 , Jeffrey W Olin  3 , Jonathan Myers  4 , John P Cooke  5 , Nicholas J Leeper  6
Affiliations

Effect of physical activity assessment on prognostication for peripheral artery disease and mortality

Peter Chang et al. Mayo Clin Proc. 2015 Mar.

Abstract

Objective: To examine whether a simple question about the performance of regular vigorous activity is associated with peripheral artery disease (PAD) and mortality.

Methods: A total of 1288 individuals undergoing nonemergency coronary angiography were assessed for participation in regular vigorous activity by questionnaire. Data on demographic characteristics, ankle-brachial indexes, and cardiovascular outcomes were prospectively collected.

Results: Compared with those who denied participation in regular vigorous activity, those who reported participation were less likely to have PAD (odds ratio, 0.58; 95% CI, 0.39-0.86), had higher ankle-brachial indexes, had better Walking Impairment Questionnaire scores (P<.001), and experienced reduced all-cause mortality rates (hazard ratio, 0.48; 95% CI, 0.31-0.74). When added to the Framingham Risk Score, the response improved the net reclassification index for all-cause (32.6%) and cardiovascular (32.0%) mortality.

Conclusion: Among at-risk individuals, regular vigorous activity is associated with decreased PAD and all-cause mortality. Simple and readily available, a single yes/no query about participation in regular vigorous exercise could be used to improve risk stratification.

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