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. 2015 Mar 23;54(13):4075-8.
doi: 10.1002/anie.201412051. Epub 2015 Feb 4.

Nickel-catalyzed enantioselective C-C bond formation through C(sp2)-O cleavage in aryl esters

Josep Cornella  1 , Evan P Jackson, Ruben Martin
Affiliations

Nickel-catalyzed enantioselective C-C bond formation through C(sp2)-O cleavage in aryl esters

Josep Cornella et al. Angew Chem Int Ed Engl. .

Abstract

We report the first enantioselective CC bond formation through CO bond cleavage using aryl ester counterparts. This method is characterized by its wide substrate scope and results in the formation of quaternary stereogenic centers with high yields and asymmetric induction.

Keywords: C-O cleavage; C-O electrophiles; aryl esters; nickel catalysis.

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