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Review
. 2015 Mar;16(3):178-89.
doi: 10.1038/nrm3941. Epub 2015 Feb 4.

Histone exchange, chromatin structure and the regulation of transcription

Swaminathan Venkatesh  1 , Jerry L Workman  1
Affiliations
Review

Histone exchange, chromatin structure and the regulation of transcription

Swaminathan Venkatesh et al. Nat Rev Mol Cell Biol. 2015 Mar.

Abstract

The packaging of DNA into strings of nucleosomes is one of the features that allows eukaryotic cells to tightly regulate gene expression. The ordered disassembly of nucleosomes permits RNA polymerase II (Pol II) to access the DNA, whereas nucleosomal reassembly impedes access, thus preventing transcription and mRNA synthesis. Chromatin modifications, chromatin remodellers, histone chaperones and histone variants regulate nucleosomal dynamics during transcription. Disregulation of nucleosome dynamics results in aberrant transcription initiation, producing non-coding RNAs. Ongoing research is elucidating the molecular mechanisms that regulate chromatin structure during transcription by preventing histone exchange, thereby limiting non-coding RNA expression.

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References

    1. Science. 2007 Mar 9;315(5817):1405-8 - PubMed
    1. EMBO J. 1991 Apr;10(4):971-80 - PubMed
    1. J Mol Biol. 2012 Sep 28;422(4):519-31 - PubMed
    1. PLoS Genet. 2012;8(5):e1002717 - PubMed
    1. Science. 2004 Dec 17;306(5704):2084-7 - PubMed

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