Boosting bacterial metabolism to combat antibiotic resistance

Prerna Bhargava¹, James J Collins²

Affiliations

¹ Institute for Medical Engineering & Science, Department of Biological Engineering, and Synthetic Biology Center, Massachusetts Institute of Technology, Cambridge, MA 02139, USA; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA; Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, MA 02115, USA.
² Institute for Medical Engineering & Science, Department of Biological Engineering, and Synthetic Biology Center, Massachusetts Institute of Technology, Cambridge, MA 02139, USA; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA; Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, MA 02115, USA. Electronic address: jimjc@mit.edu.

PMID: 25651168
DOI: 10.1016/j.cmet.2015.01.012

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Boosting bacterial metabolism to combat antibiotic resistance

Prerna Bhargava et al. Cell Metab. 2015.

Free article

. 2015 Feb 3;21(2):154-155.

doi: 10.1016/j.cmet.2015.01.012.

Authors

Prerna Bhargava¹, James J Collins²

Affiliations

¹ Institute for Medical Engineering & Science, Department of Biological Engineering, and Synthetic Biology Center, Massachusetts Institute of Technology, Cambridge, MA 02139, USA; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA; Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, MA 02115, USA.
² Institute for Medical Engineering & Science, Department of Biological Engineering, and Synthetic Biology Center, Massachusetts Institute of Technology, Cambridge, MA 02139, USA; Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA; Wyss Institute for Biologically Inspired Engineering, Harvard University, Boston, MA 02115, USA. Electronic address: jimjc@mit.edu.

PMID: 25651168
DOI: 10.1016/j.cmet.2015.01.012

Abstract

The metabolic state of a bacterial cell influences its susceptibility to antibiotics. In this issue, Peng et al. (2015) show that resistant bacteria can be sensitized to antibiotic treatment through the addition of exogenous metabolites that stimulate central metabolic pathways and increase drug uptake.

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Exogenous alanine and/or glucose plus kanamycin kills antibiotic-resistant bacteria.
Peng B, Su YB, Li H, Han Y, Guo C, Tian YM, Peng XX. Peng B, et al. Cell Metab. 2015 Feb 3;21(2):249-262. doi: 10.1016/j.cmet.2015.01.008. Cell Metab. 2015. PMID: 25651179

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Boosting bacterial metabolism to combat antibiotic resistance

Affiliations

Boosting bacterial metabolism to combat antibiotic resistance

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Medical