Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2015 Feb 2:26:26191.
doi: 10.3402/mehd.v26.26191. eCollection 2015.

Dysbiosis of the gut microbiota in disease

Affiliations

Dysbiosis of the gut microbiota in disease

Simon Carding et al. Microb Ecol Health Dis. .

Abstract

There is growing evidence that dysbiosis of the gut microbiota is associated with the pathogenesis of both intestinal and extra-intestinal disorders. Intestinal disorders include inflammatory bowel disease, irritable bowel syndrome (IBS), and coeliac disease, while extra-intestinal disorders include allergy, asthma, metabolic syndrome, cardiovascular disease, and obesity.

Keywords: Microbiome; colonic metabolome; gut health; gut–brain–axis; inflammation; short-chain fatty acids.

PubMed Disclaimer

Similar articles

Cited by

References

    1. Savage DC. Microbial ecology of the gastrointestinal tract. Ann Rev Microbiol. 1977;31:107–33. - PubMed
    1. Reyes A, Haynes M, Hanson N, Angly FE, Heath AC, Rohwer F, et al. Viruses in the faecal microbiota of monozygotic twins and their mothers. Nature. 2010;466:334–8. - PMC - PubMed
    1. Kamada N, Seo SU, Chen GY, Nunez G. Role of the gut microbiota in immunity and inflammatory disease. Nat Rev Immunol. 2013;13:321–35. - PubMed
    1. Tanoue T, Umesaki Y, Honda K. Immune responses to gut microbiota-commensals and pathogens. Gut Microbes. 2010;1:224–33. - PMC - PubMed
    1. Wen L, Ley RE, Volchkov PY, Stranges PB, Avanesyan L, Stonebraker AC, et al. Innate immunity and intestinal microbiota in the development of Type 1 diabetes. Nature. 2008;455:1109–13. - PMC - PubMed