Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comment
. 2015 May-Jun;17(3):443-4.
doi: 10.4103/1008-682X.142140.

From PAWP to "Pop": opening up new pathways to fatherhood

Affiliations
Comment

From PAWP to "Pop": opening up new pathways to fatherhood

Melissa L Vadnais et al. Asian J Androl. 2015 May-Jun.

Abstract

Infertility remains a significant problem for many couples. Approximately one in seven couples who attempt to conceive will fail to do so within 1 year. In about 65% of these cases, there is a male component of infertility.1 Despite normal semen parameters, the etiology of infertility remains uncertain in more than 50% of couples.2 Defects in sperm proteins and/ or structures may underlie certain cases of male infertility. Although many men would like to be called "Pop", "Dad", or "Papa", those who are classified with idiopathic male infertility have few options for becoming fathers. Recent studies by Aarabi et al.3 may open the door to new therapies.

PubMed Disclaimer

Comment on

References

    1. Niederberger C, Joyce G, Wise M, Meacham R. Urologic Diseases in America. In: Litwin M, Saigal CS, editors. Washington, DC: US Department of Health and Human Services, Public Health Service, National Institutes of Health, National Institute of Diabetes and Digestive and Kidney Diseases (US Government Printing Office, 2007); 2007.
    1. Shukla KK, Mahdi AA, Rajender S. Apoptosis, spermatogenesis and male infertility. Front Biosci (Elite Ed) 2012;4:746–54. - PubMed
    1. Aarabi M, Balakier H, Bashar S, Moskovtsev SI, Sutovsky P, et al. Sperm-derived WW domain-binding protein, PAWP, elicits calcium oscillations and oocyte activation in humans and mice. FASEB J. 2014;28:4434–40. - PubMed
    1. Whitaker M. Calcium at fertilization and in early development. Physiol Rev. 2006;86:25–88. - PMC - PubMed
    1. Ito J, Parrington J, Fissore RA. PLCζ and its role as a trigger of development in vertebrates. Mol Reprod Dev. 2011;78:846–53. - PubMed