From PAWP to "Pop": opening up new pathways to fatherhood
- PMID: 25652617
- PMCID: PMC4430948
- DOI: 10.4103/1008-682X.142140
From PAWP to "Pop": opening up new pathways to fatherhood
Abstract
Infertility remains a significant problem for many couples. Approximately one in seven couples who attempt to conceive will fail to do so within 1 year. In about 65% of these cases, there is a male component of infertility.1 Despite normal semen parameters, the etiology of infertility remains uncertain in more than 50% of couples.2 Defects in sperm proteins and/ or structures may underlie certain cases of male infertility. Although many men would like to be called "Pop", "Dad", or "Papa", those who are classified with idiopathic male infertility have few options for becoming fathers. Recent studies by Aarabi et al.3 may open the door to new therapies.
Comment on
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Sperm-derived WW domain-binding protein, PAWP, elicits calcium oscillations and oocyte activation in humans and mice.FASEB J. 2014 Oct;28(10):4434-40. doi: 10.1096/fj.14-256495. Epub 2014 Jun 26. FASEB J. 2014. PMID: 24970390
References
-
- Niederberger C, Joyce G, Wise M, Meacham R. Urologic Diseases in America. In: Litwin M, Saigal CS, editors. Washington, DC: US Department of Health and Human Services, Public Health Service, National Institutes of Health, National Institute of Diabetes and Digestive and Kidney Diseases (US Government Printing Office, 2007); 2007.
-
- Shukla KK, Mahdi AA, Rajender S. Apoptosis, spermatogenesis and male infertility. Front Biosci (Elite Ed) 2012;4:746–54. - PubMed
-
- Aarabi M, Balakier H, Bashar S, Moskovtsev SI, Sutovsky P, et al. Sperm-derived WW domain-binding protein, PAWP, elicits calcium oscillations and oocyte activation in humans and mice. FASEB J. 2014;28:4434–40. - PubMed
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- Ito J, Parrington J, Fissore RA. PLCζ and its role as a trigger of development in vertebrates. Mol Reprod Dev. 2011;78:846–53. - PubMed
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