Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comment
. 2015 May-Jun;17(3):446-9.
doi: 10.4103/1008-682X.145071.

Re: Is PAWP the 'real' sperm factor?

Mahmoud Aarabi, Peter Sutovsky, Richard Oko  1
Affiliations
Comment

Re: Is PAWP the 'real' sperm factor?

Mahmoud Aarabi et al. Asian J Androl. 2015 May-Jun.

Abstract

Mammalian embryo development is init iated by intracel lular Ca2+ oscillations that result in oocyte activation following gamete membrane fusion. It is widely believed that oocyte Ca2+ oscillations are triggered by a sperm-specific protein, phospholipase C-zeta (PLCζ) that activates InsP3 production leading to repetitive Ca2+ release from intracellular stores. However, a recent report in the FASEB Journal by Aarabi et al. challenges this view by proposing postacrosomal WW domain-binding protein (PAWP) as another sperm-derived protein that can also initiate Ca2+ oscillations and zygotic development at fertilization. Here we discuss these new findings and examine the evidence suggesting PAWP as the "real" sperm factor.

PubMed Disclaimer

Comment on

References

    1. Aarabi M, Balakier H, Bashar S, Moskovtsev SI, Sutovsky P, et al. Sperm-derived WW domain-binding protein, PAWP, elicits calcium oscillations and oocyte activation in humans and mice. FASEB J. 2014;28:4434–40. - PubMed
    1. Aarabi M, Qin Z, Xu W, Mewburn J, Oko R. Sperm-borne protein, PAWP, initiates zygotic development in Xenopus laevis by eliciting intracellular calcium release. Mol Reprod Dev. 2010;77:249–56. - PubMed
    1. Wu AT, Sutovsky P, Manandhar G, Xu W, Katayama M, et al. PAWP, a sperm-specific WW domain-binding protein, promotes meiotic resumption and pronuclear development during fertilization. J Biol Chem. 2007;282:12164–75. - PubMed
    1. Wu AT, Sutovsky P, Xu W, van der Spoel AC, Platt FM, et al. The postacrosomal assembly of sperm head protein, PAWP, is independent of acrosome formation and dependent on microtubular manchette transport. Dev Biol. 2007;312:471–83. - PubMed
    1. Yoon SY, Jellerette T, Salicioni AM, Lee HC, Yoo MS, et al. Human sperm devoid of PLC, zeta 1 fail to induce Ca (2+) release and are unable to initiate the first step of embryo development. J Clin Invest. 2008;118:3671–81. - PMC - PubMed