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. 2015 Oct;16(5):1041-50.
doi: 10.1208/s12249-015-0296-y. Epub 2015 Feb 6.

Formulation of Eco-friendly Medicated Chewing Gum to Prevent Motion Sickness

Rahul B Shete  1 , Vimalkumar J Muniswamy  1 , Ashlesha P Pandit  2 , Kishanchandra R Khandelwal  1
Affiliations

Formulation of Eco-friendly Medicated Chewing Gum to Prevent Motion Sickness

Rahul B Shete et al. AAPS PharmSciTech. 2015 Oct.

Abstract

An attempt was made to formulate medicated chewing gum to prevent motion sickness using natural gum base for faster onset of action and easy administration, anywhere and anytime, without access to water. To avoid the discard issue of gum cud, natural gum base of Triticum aestivum (wheat grain) was explored because of its biodegradable and biocompatible nature and easy availability. Prolamin, extracted from wheat, showed good chewing capacity, elasticity, high water retention capacity, antifungal activity, and compatibility with the drug. Formulations were prepared based on a two-factor and three-level factorial design. Amount of calcium carbonate (texturizer) and gum base were selected as independent variables. Elasticity and drug release were considered as the dependent variables. All batches were evaluated for the content uniformity, elasticity study, texture study, in vitro drug release study, and chewiness study. Results revealed that medicated chewing gum containing 80 mg of calcium carbonate and 500 mg of gum base showed good elasticity and more than 90% drug release within 16 min. Thus, this study suggested that both good elasticity and chew ability and abundant availability of wheat grain can act as a potential gum base for medicated chewing gum.

Keywords: biodegradable gum; gum base; medicated chewing gum; plasticizer; wheat prolamin.

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Figures

Fig. 1
Fig. 1
Zone of inhibition showing antifungal activity of chewing gum base. A is gum base concentration (1000 μg/mL), B is gum base concentration (100 μg/mL), and C is control
Fig. 2
Fig. 2
Elasticity study of the medicated chewing gum
Fig. 3
Fig. 3
In vitro dissolution profile of medicated chewing gum
Fig. 4
Fig. 4
Buccal absorption test
Fig. 5
Fig. 5
Contour plot showing effect of factors on elasticity
Fig. 6
Fig. 6
Response surface plot showing combined effect of factors on elasticity
Fig. 7
Fig. 7
Contour plot showing effect of factors on drug release
Fig. 8
Fig. 8
Response surface plot showing combined effect of factors on drug release
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