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. 2015 Mar 9;54(11):3216-21.
doi: 10.1002/anie.201410288. Epub 2015 Feb 4.

Late-stage fluorination: fancy novelty or useful tool?

Constanze N Neumann  1 , Tobias Ritter
Affiliations

Late-stage fluorination: fancy novelty or useful tool?

Constanze N Neumann et al. Angew Chem Int Ed Engl. .

Abstract

Charming fluorine: This Essay examines the recent surge in late-stage fluorination reactions and outlines challenges that need to be overcome to increase the impact of modern fluorination methods on the synthesis of complex organofluorine compounds. It is outlined how an improved understanding of the bonding interactions of fluoride could lead to a new class of mild fluorinating reagents and a range of functional-group-tolerant reactions.

Keywords: fluorination; organocatalysis; positron emission tomography; radiochemistry; transition-metal catalysis.

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