Cardiac risk in the treatment of breast cancer: assessment and management
- PMID: 25653554
- PMCID: PMC4303336
- DOI: 10.2147/BCTT.S47227
Cardiac risk in the treatment of breast cancer: assessment and management
Abstract
As the number of long-term breast cancer survivors has increased, the side effects of adjuvant cancer therapy, such as cardiac toxicity, remain clinically important. Although the cardiac toxicity due to anthracyclines, radiotherapy, or trastuzumab is well-documented, several issues need to be clarified and are the subjects of extensive ongoing clinical research. This review summarizes the incidence of cardiac toxicity due to breast cancer adjuvant therapy and highlights the current trends in early detection and management of cardiac toxicities.
Keywords: adjuvant; anthracyclines; cardiac toxicity; radiotherapy; trastuzumab.
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References
-
- GLOBOCAN 2012: Estimated Cancer Incidence, Mortality and Prevalence Worldwide in 2012 [webpage on the Internet] Lyon: International Agency for Research on Cancer; 2012. [Accessed October 10, 2014]. Available from: http://globocan.iarc.fr/Pages/fact_sheets_cancer.aspx.
-
- Siegel R, Naishadham D, Jemal A. Cancer statistics, 2012. CA Cancer J Clin. 2012;62(1):10–29. - PubMed
-
- Early Breast Cancer Trialists’ Collaborative Group (EBCTCG) Darby S, McGale P, et al. Effect of radiotherapy after breast-conserving surgery on 10-year recurrence and 15-year breast cancer death: meta-analysis of individual patient data for 10,801 women in 17 randomised trials. Lancet. 2011;378(9804):1707–1716. - PMC - PubMed
-
- Recht A, Edge SB, Solin LJ, et al. Postmastectomy radiotherapy: clinical practice guidelines of the American Society of Clinical Oncology. J Clin Oncol. 2001;19(5):1539–1569. - PubMed
-
- EBCTCG (Early Breast Cancer Trialists’ Collaborative Group) McGale P, Taylor C. Effect of radiotherapy after mastectomy and axillary surgery on 10-year recurrence and 20-year breast cancer mortality: meta-analysis of individual patient data for 8135 women in 22 randomised trials. Lancet. 2014;383(9935):2127–2135. - PMC - PubMed
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