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. 1989 Jan;52(1):112-4.
doi: 10.1136/jnnp.52.1.112.

Tyrosine hydroxylase and levodopa responsive dystonia

N A Fletcher  1 , I J Holt, A E Harding, T G Nygaard, J Mallet, C D Marsden
Affiliations

Tyrosine hydroxylase and levodopa responsive dystonia

N A Fletcher et al. J Neurol Neurosurg Psychiatry. 1989 Jan.

Abstract

It has been suggested that a form of inherited dystonia responsive to levodopa might be due to an abnormality of tyrosine hydroxylase gene. This hypothesis has been tested using a cDNA tyrosine hydroxylase gene probe in three families with this disorder. No evidence for genetic linkage between the disease and tyrosine hydroxylase loci was found; it is possible that the disorder results from a post-transcriptional defect confined to the brain.

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