Comment
doi: 10.1016/j.neuron.2015.01.021.
Anti-inflammatory signaling in microglia exacerbates Alzheimer's disease-related pathology
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- PMID: 25654250
- DOI: 10.1016/j.neuron.2015.01.021
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Comment
Anti-inflammatory signaling in microglia exacerbates Alzheimer's disease-related pathology
Neuron.
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Free article
Abstract
In this issue of Neuron, Chakrabarty et al. (2015) and Guillot-Sestier et al. (2015) reveal that the anti-inflammatory cytokine IL-10 inhibits Aβ clearance by microglia, worsening cognitive decline in mouse models of Alzheimer's disease (AD). These studies provide further support that pro-inflammatory signaling is an innate immune defense mechanism in AD.
Copyright © 2015 Elsevier Inc. All rights reserved.
Comment on
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IL-10 alters immunoproteostasis in APP mice, increasing plaque burden and worsening cognitive behavior.Neuron. 2015 Feb 4;85(3):519-33. doi: 10.1016/j.neuron.2014.11.020. Epub 2015 Jan 22. Neuron. 2015. PMID: 25619653 Free PMC article.
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Il10 deficiency rebalances innate immunity to mitigate Alzheimer-like pathology.Neuron. 2015 Feb 4;85(3):534-48. doi: 10.1016/j.neuron.2014.12.068. Epub 2015 Jan 22. Neuron. 2015. PMID: 25619654 Free PMC article.
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