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Review
. 2015 Jul 15;6(7):1026-39.
doi: 10.1021/cn5003573. Epub 2015 Feb 19.

Serotonergic Systems in the Pathophysiology of Ethanol Dependence: Relevance to Clinical Alcoholism

Catherine A Marcinkiewcz  1
Affiliations
Review

Serotonergic Systems in the Pathophysiology of Ethanol Dependence: Relevance to Clinical Alcoholism

Catherine A Marcinkiewcz. ACS Chem Neurosci. .

Abstract

Alcoholism is a progressive brain disorder that is marked by increased sensitivity to the positive and negative reinforcing properties of ethanol, compulsive and habitual use despite negative consequences, and chronic relapse to alcohol drinking despite repeated attempts to reduce intake or abstain from alcohol. Emerging evidence from preclinical and clinical studies implicates serotonin (5-hydroxytryptamine; 5-HT) systems in the pathophysiology of alcohol dependence, suggesting that drugs targeting 5-HT systems may have utility in the treatment of alcohol use disorders. In this Review, we discuss the role of 5-HT systems in alcohol dependence with a focus on 5-HT interactions with neural circuits that govern all three stages of the addiction cycle. We attempt to clarify how 5-HT influences circuit function at these different stages with the goal of identifying neural targets for pharmacological treatment of this debilitating disorder.

Keywords: 5-HT2C receptors; SSRIs; Serotonin; alcohol; anxiety; withdrawal.

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Conflict of interest statement

Notes

The author declares no competing financial interest.

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