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Review
. 2015;6(3):244-8.
doi: 10.1080/21505594.2014.999570.

HPV and cancer of the oral cavity

Christian U Hübbers  1 , Baki Akgül
Affiliations
Review

HPV and cancer of the oral cavity

Christian U Hübbers et al. Virulence. 2015.

Abstract

Increased awareness of human papillomavirus (HPV) as an etiological cause of head and neck squamous cell carcinoma has increased the interest in analysis of distinct oral sub-sites. It is currently under debate, whether HPV plays a role in the development of squamous cell carcinoma of the oral cavity (OSCC). The weakness in most published studies is the lack of performing different HPV detection tests combined with analysis for biological activity of the virus. In addition, different sub-sites of the oral cavity had been combined to a single entity, which retrospectively leads to a highly heterogeneous basis of data. In this review we mainly discuss the unclear role of HPV in OSCC development.

Keywords: HNSCC, head and neck squamous cell carcinoma; HPV; Head and neck cancer; Human papillomavirus,oral squamous cell cancer; OPSCC, oropharyngeal squamous cell carcinoma; OSCC, oral squamous cell carcinoma.; human papillomavirus.

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References

    1. Ferlay J, Shin HR, Bray F, Forman D, Mathers C, Parkin DM. Estimates of worldwide burden of cancer in 2008: GLOBOCAN 2008. Int J Cancer 2010; 127:2893-917; PMID:21351269; http://dx.doi.org/10.1002/ijc.25516 - DOI - PubMed
    1. Rautava J, Syrjanen S. Human papillomavirus infections in the oral mucosa. J Am Dent Assoc 2011; 142:905-14; PMID:21804057; http://dx.doi.org/10.14219/jada.archive.2011.0297 - DOI - PubMed
    1. Hashibe M, Sturgis EM. Epidemiology of oral-cavity and oropharyngeal carcinomas: controlling a tobacco epidemic while a human papillomavirus epidemic emerges. Otolaryngol clin North Am 2013; 46:507-20; PMID:23910467; http://dx.doi.org/10.1016/j.otc.2013.05.001 - DOI - PubMed
    1. Kim L, King T, Agulnik M. Head and neck cancer: changing epidemiology and public health implications. Oncology 2010; 24:915-9, 24; PMID:21138172 - PubMed
    1. Jayaprakash V, Reid M, Hatton E, Merzianu M, Rigual N, Marshall J, Gill S, Frustino J, Wilding G, Loree T, et al. . Human papillomavirus types 16 and 18 in epithelial dysplasia of oral cavity and oropharynx: a meta-analysis, 1985-2010. Oral oncol 2011; 47:1048-54; PMID:21816661; http://dx.doi.org/10.1016/j.oraloncology.2011.07.009 - DOI - PMC - PubMed

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