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Comment
. 2015 Feb;21(2):109-10.
doi: 10.1038/nm.3790.

Response to burgess

Douglas E Befroy  1 , Richard G Kibbey  2 , Rachel J Perry  2 , Kitt Falk Petersen  3 , Douglas L Rothman  4 , Gerald I Shulman  5
Affiliations
Comment

Response to burgess

Douglas E Befroy et al. Nat Med. 2015 Feb.
No abstract available

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Conflict of interest statement

COMPETING FINANCIAL INTERESTS

The authors declare no competing financial interests.

Figures

Figure 1
Figure 1
The effect of pyruvate cycling, expressed as VPK/VTCA, on the kinetics of hepatic [1-13C]glutamate (13C1-Glu) enrichment during a 2-h infusion of [1-13C]acetate. Raw data (black diamonds) are reproduced from Befroy et al.. Low rates of VPK clearly fit the experimental data better than the higher values suggested by Burgess et al.. All studies were approved by the Yale Human Investigation Committee, and informed written consent was obtained from all subjects.
Figure 2
Figure 2
13C spectra acquired from human liver at baseline (gray) and after an infusion of [3-13C]lactate (black). Negligible enrichment at alanine C2 and lactate C2 compared to their C3 counterparts (inset, acquired during the same study under identical conditions and shown at the same scale) indicate that VPK/VTCA is low. All studies were approved by the Yale Human Investigation Committee, and informed written consent was obtained from all subjects.
See this image and copyright information in PMC

Comment on

References

    1. Burgess SC, et al. Nat Med. 2015;21:108–109. - PMC - PubMed
    1. Befroy DE, et al. Nat Med. 2014;20:98–102. - PMC - PubMed
    1. Petersen KF, et al. Metabolism. 1995;44:1380–1383. - PubMed
    1. Petersen KF, et al. Am J Physiol. 1994;267:E273–E277. - PubMed
    1. Sunny NE, et al. Cell Metab. 2011;14:804–810. - PMC - PubMed

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