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Review
. 2015 Mar;12(1):25-32.
doi: 10.1007/s11904-014-0247-3.

Understanding frailty, aging, and inflammation in HIV infection

Sean X Leng  1 , Joseph B Margolick
Affiliations
Review

Understanding frailty, aging, and inflammation in HIV infection

Sean X Leng et al. Curr HIV/AIDS Rep. 2015 Mar.

Abstract

Frailty is a clinical syndrome initially characterized in geriatric populations with a hallmark of age-related declines in physiologic reserve and function and increased vulnerability to adverse health outcomes. Recently, frailty has increasingly been recognized as a common and important HIV-associated non-AIDS (HANA) condition. This article provides an overview of our current understanding of frailty and its phenotypic characteristics and evidence that they are related to aging and to chronic inflammation that is associated with aging and also with long-term treated HIV infection. The etiology of this chronic inflammation is unknown but we discuss evidence linking it to persistent infection with cytomegalovirus in both geriatric populations and people living with HIV infection.

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References

    1. Desquilbet L, Jacobson L, Fried LP, Phair JP, Williams CM, Jamieson BD, et al. HIV-1 infection is associated with an earlier occurrence of a phenotype related to frailty. J Gerontol A Biol Sci Med Sci. 2007;62:1279–1286. - PubMed
    1. Piggott DA, Muzaale AD, Mehta SH, Brown TT, Patel KV, Leng SX, et al. Frailty, HIV infection, and mortality in an aging cohort of injection drug users. PLoS ONE. 2013;8(1):e54910. This study demonstrated the prognostic import of frailty in a cohort of injection drug users with HIV infcction. - PMC - PubMed
    1. Desquilbet L, Margolick JB, Fried LP, Phair JP, Jamieson BD, Holloway M, et al. Relationship between a frailty-related phenotype and progressive deterioration of the immune system in HIV-1 infected men. J Acquir Immun Defic Syndr. 2009;50:299–306. This study illustrated the relationship between the frailty-related phenotype studied and the CD4 cell count in HIV-infected and -uninfected men who have sex with men. - PMC - PubMed
    1. Terzian AS, Holman S, Nathwani N, Robison E, Weber K, Young M, et al. Factors associated with preclinical disability and frailty among HIV-infected and HIV-uninfected women in the era of cART. J Womens Health (Larchmt) 2009;18(12):1965–1974. - PMC - PubMed
    1. Pathai S, Gilbert C, Weiss HA, Cook C, Wood R, Bekker LG, et al. Frailty in HIV-infected adults in South Africa. J Acquir Immune Defic Syndr. 2013;62(1):43–51. - PMC - PubMed

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