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Editorial
. 2015 Apr;14(4):489-92.
doi: 10.1586/14760584.2015.1011135. Epub 2015 Feb 6.

IL-33 isoforms: their future as vaccine adjuvants?

Daniel O Villarreal  1 , David B Weiner
Affiliations
Editorial

IL-33 isoforms: their future as vaccine adjuvants?

Daniel O Villarreal et al. Expert Rev Vaccines. 2015 Apr.

Abstract

The identification and characterization of cytokine isoforms is likely to provide critical important new insight into immunobiology. Cytokine isoforms can provide additional diversity to their complex biological effects that participate in control and protection against different foreign pathogens. Recently, IL-33 has been identified as a proinflammatory cytokine having several different biologically active isoform products. Originally associated with Th2 immunity, new evidence now supports the role of two IL-33 isoforms to facilitate the generation of protective Th1 and CD8 T cell immunity against specific pathogens. Therefore, a better understanding of the IL-33 isoforms will inform us on how to utilize them to facilitate their development as tools as vaccine adjuvants for immune therapy.

Keywords: CD8 T cell; DNA vaccine; IL 33; adjuvant; cancer vaccine; cytokine; immunotherapies; isoform.

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Conflict of interest statement

Competing interests disclosure: The other authors declare no competing financial interests.

No writing assistance was utilized in the production of this manuscript.

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