Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2015 Jan-Feb;60(1):105.
doi: 10.4103/0019-5154.147870.

Extra Mammary Paget's Disease: A Rare Case Report

Vidyadhar R Sardesai  1 , Trupti D Agarwal  1 , Sarita P Sakhalkar  1
Affiliations

Extra Mammary Paget's Disease: A Rare Case Report

Vidyadhar R Sardesai et al. Indian J Dermatol. 2015 Jan-Feb.

Abstract

Extramammary Paget's disease is a marginated plaque resembling Paget's disease but occurring in anogenital area, axilla or most commonly on the vulva. A 62-year-old postmenopausal woman presented with extremely pruritic plaque on the perineal skin which progressed gradually over 3 years and did not respond to any topical/systemic steroids, antibiotics, and antifungals. Examination revealed 7 × 8 cm. hypertrophic, verrucous plaque with erosions, and crusts at places. There was no evidence of visceral malignancy. Biopsy showed Paget's cells which were positive for Periodic Acid Schiff and alcian blue stain. Surgical excision was done considering the premalignant potential.

Keywords: Extramammary Paget's disease; paget's cells; pruritus.

PubMed Disclaimer

Conflict of interest statement

Conflict of Interest: Nil.

Figures

Figure 1
Figure 1
Lesion on perineal area
Figure 2
Figure 2
Erosions and crusts over the plaque
Figure 3
Figure 3
Paget's cells in H and E stain ×10
Figure 4
Figure 4
Paget's cells in PAS stain ×40
See this image and copyright information in PMC

References

    1. Crocker HR. “Paget's disease affecting the scrotum and penis,” Transcript. Pathological Society of London. 1888;40:187.
    1. Banerjee S, Chatterjee M, Chand K. Extramammary Paget’ disease. Indian J Dermatol Venereol Leprol. 2005;71:417–20. - PubMed
    1. Lloyd J, Flanagan AM. Mammary and extramammary Paget's disease. J Clin Pathol. 2000;53:742–9. - PMC - PubMed
    1. Shepherd V, Davidson EJ, Davies-Humphreys J. Extramammary Paget's disease. BJOG. 2005;112:273–9. - PubMed
    1. MacKie RM. Epidermal skin tumours. In: Champion RH, Burton JL, Burns DA, Breathnach SM, editors. Rook/Wilkinson/Ebling Textbook of dermatology. 6th ed. Oxford: Blackwell Science; 1998. pp. 1678–9.

LinkOut - more resources