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Review
. 2014 Dec 31:7:53-64.
doi: 10.2147/CLEP.S73728. eCollection 2015.

The Western Denmark Cardiac Computed Tomography Registry: a review and validation study

Lene Hüche Nielsen  1 , Bjarne Linde Nørgaard  2 , Hans Henrik Tilsted  3 , Niels Peter Sand  4 , Jesper Møller Jensen  2 , Morten Bøttcher  5 , Axel C Diederichsen  6 , Jess Lambrechtsen  7 , Lone Deibjerg Kristensen  8 , Hans Mickley  6 , Henrik Munkholm  1 , Ole Gøtzsche  2 , Lars Lyhne Knudsen  5 , Hans Erik Bøtker  2 , Lars Pedersen  9 , Morten Schmidt  10
Affiliations
Review

The Western Denmark Cardiac Computed Tomography Registry: a review and validation study

Lene Hüche Nielsen et al. Clin Epidemiol. .

Abstract

Background: As a subregistry to the Western Denmark Heart Registry (WDHR), the Western Denmark Cardiac Computed Tomography Registry (WDHR-CCTR) is a clinical database established in 2008 to monitor and improve the quality of cardiac computed tomography (CT) in Western Denmark.

Objective: We examined the content, data quality, and research potential of the WDHR-CCTR.

Methods: We retrieved 2008-2012 data to examine the 1) content; 2) completeness of procedure registration using the Danish National Patient Registry as reference; 3) completeness of variable registration comparing observed vs expected numbers; and 4) positive predictive values as well as negative predictive values of 19 main patient and procedure variables.

Results: By December 31, 2012, almost 22,000 cardiac CTs with up to 40 variables for each procedure have been registered. Of these, 87% were coronary CT angiography performed in patients with symptoms indicative of coronary artery disease. Compared with the Danish National Patient Registry, the overall procedure completeness was 72%. However, an additional medical record review of 282 patients registered in the Danish National Patient Registry, but not in the WDHR-CCTR, showed that coronary CT angiographies accounted for only 23% of all nonregistered cardiac CTs, indicating >90% completeness of coronary CT angiographies in the WDHR-CCTR. The completeness of individual variables varied substantially (range: 0%-100%), but was >85% for more than 70% of all variables. Using medical record review of 250 randomly selected patients as reference standard, the positive predictive value for the 19 variables ranged from 89% to 100% (overall 97%), whereas the negative predictive value ranged from 97% to 100% (overall 99%). Stratification by center status showed consistently high positive and negative predictive values for both university (96%/99%) and nonuniversity centers (97%/99%).

Conclusion: WDHR-CCTR provides ongoing prospective registration of all cardiac CTs performed in Western Denmark since 2008. Overall, the registry data have a high degree of completeness and validity, making it a valuable tool for clinical epidemiological research.

Keywords: coronary computed tomography angiography; database; epidemiology; registries.

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Figures

Figure 1
Figure 1
Cardiac centers reporting to Western Denmark Cardiac Computed Tomography Registry. Notes: Color codings indicate the five regions of Denmark. Numbers indicate the cardiac centers reporting to the registry: (1) Vendsyssel Hospital; (2) Aalborg University Hospital; (3) Regional Hospital Herning; (4) Regional Hospital Silkeborg; (5) Aarhus University Hospital (previously comprising two separate cardiac centers); (6) Lillebaelt Hospital-Vejle; (7) Hospital of Southwestern Denmark-Esbjerg; (8) Odense University Hospital; and (9) Odense University Hospital-Svendborg Hospital.
Figure 2
Figure 2
Number of patients having cardiac computed tomography (CT) registered in the Western Denmark Cardiac Computed Tomography Registry (WDHR-CCTR) and the Danish National Patient Registry (DNPR), 2008–2012.
Figure 3
Figure 3
Proportion of patients having a cardiac computed tomography registered in both the Western Denmark Cardiac Computed Tomography Registry (WDHR-CCTR) and the Danish National Patient Registry (DNPR) during 2008–2012.
See this image and copyright information in PMC

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