Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2014 Dec 31:7:53-64.
doi: 10.2147/CLEP.S73728. eCollection 2015.

The Western Denmark Cardiac Computed Tomography Registry: a review and validation study

Lene Hüche Nielsen  1 , Bjarne Linde Nørgaard  2 , Hans Henrik Tilsted  3 , Niels Peter Sand  4 , Jesper Møller Jensen  2 , Morten Bøttcher  5 , Axel C Diederichsen  6 , Jess Lambrechtsen  7 , Lone Deibjerg Kristensen  8 , Hans Mickley  6 , Henrik Munkholm  1 , Ole Gøtzsche  2 , Lars Lyhne Knudsen  5 , Hans Erik Bøtker  2 , Lars Pedersen  9 , Morten Schmidt  10
Affiliations
Review

The Western Denmark Cardiac Computed Tomography Registry: a review and validation study

Lene Hüche Nielsen et al. Clin Epidemiol. .

Abstract

Background: As a subregistry to the Western Denmark Heart Registry (WDHR), the Western Denmark Cardiac Computed Tomography Registry (WDHR-CCTR) is a clinical database established in 2008 to monitor and improve the quality of cardiac computed tomography (CT) in Western Denmark.

Objective: We examined the content, data quality, and research potential of the WDHR-CCTR.

Methods: We retrieved 2008-2012 data to examine the 1) content; 2) completeness of procedure registration using the Danish National Patient Registry as reference; 3) completeness of variable registration comparing observed vs expected numbers; and 4) positive predictive values as well as negative predictive values of 19 main patient and procedure variables.

Results: By December 31, 2012, almost 22,000 cardiac CTs with up to 40 variables for each procedure have been registered. Of these, 87% were coronary CT angiography performed in patients with symptoms indicative of coronary artery disease. Compared with the Danish National Patient Registry, the overall procedure completeness was 72%. However, an additional medical record review of 282 patients registered in the Danish National Patient Registry, but not in the WDHR-CCTR, showed that coronary CT angiographies accounted for only 23% of all nonregistered cardiac CTs, indicating >90% completeness of coronary CT angiographies in the WDHR-CCTR. The completeness of individual variables varied substantially (range: 0%-100%), but was >85% for more than 70% of all variables. Using medical record review of 250 randomly selected patients as reference standard, the positive predictive value for the 19 variables ranged from 89% to 100% (overall 97%), whereas the negative predictive value ranged from 97% to 100% (overall 99%). Stratification by center status showed consistently high positive and negative predictive values for both university (96%/99%) and nonuniversity centers (97%/99%).

Conclusion: WDHR-CCTR provides ongoing prospective registration of all cardiac CTs performed in Western Denmark since 2008. Overall, the registry data have a high degree of completeness and validity, making it a valuable tool for clinical epidemiological research.

Keywords: coronary computed tomography angiography; database; epidemiology; registries.

PubMed Disclaimer

Figures

Figure 1
Figure 1
Cardiac centers reporting to Western Denmark Cardiac Computed Tomography Registry. Notes: Color codings indicate the five regions of Denmark. Numbers indicate the cardiac centers reporting to the registry: (1) Vendsyssel Hospital; (2) Aalborg University Hospital; (3) Regional Hospital Herning; (4) Regional Hospital Silkeborg; (5) Aarhus University Hospital (previously comprising two separate cardiac centers); (6) Lillebaelt Hospital-Vejle; (7) Hospital of Southwestern Denmark-Esbjerg; (8) Odense University Hospital; and (9) Odense University Hospital-Svendborg Hospital.
Figure 2
Figure 2
Number of patients having cardiac computed tomography (CT) registered in the Western Denmark Cardiac Computed Tomography Registry (WDHR-CCTR) and the Danish National Patient Registry (DNPR), 2008–2012.
Figure 3
Figure 3
Proportion of patients having a cardiac computed tomography registered in both the Western Denmark Cardiac Computed Tomography Registry (WDHR-CCTR) and the Danish National Patient Registry (DNPR) during 2008–2012.
See this image and copyright information in PMC

References

    1. Bonow RO, Mann DL, Zipes DP, Libby P. Braunwald’s Heart Disease: a Textbook of Cardiovascular Medicine. 9th ed. Philadelphia, PA: Saunders; 2012.
    1. Montalescot G, Sechtem U, Achenbach S, et al. 2013 ESC guidelines on the management of stable coronary artery disease: the Task Force on the management of stable coronary artery disease of the European Society of Cardiology. Eur Heart J. 2013;34(38):2949–3003. - PubMed
    1. Fihn SD, Gardin JM, Abrams J, et al. 2012 ACCF/AHA/ACP/AATS/PCNA/SCAI/STS Guideline for the diagnosis and management of patients with stable ischemic heart disease: a report of the American College of Cardiology Foundation/American Heart Association Task Force on Practice Guidelines, and the American College of Physicians, American Association for Thoracic Surgery, Preventive Cardiovascular Nurses Association, Society for Cardiovascular Angiography and Interventions, and Society of Thoracic Surgeons. J Am Coll Cardiol. 2012;60(24):e44–e164. - PubMed
    1. Schmidt M, Maeng M, Jakobsen CJ, et al. Existing data sources for clinical epidemiology: The Western Denmark Heart Registry. Clin Epidemiol. 2010;2:137–144. - PMC - PubMed
    1. The board of Western Denmark Heart Registry Western Denmark Heart Registry: Annual Report 2008 (Data from 2007 and 2008) 2009.