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Review
. 2015;2(1):1-8.
doi: 10.1007/s40496-014-0039-2.

Host Responses in the Link Between Periodontitis and Rheumatoid Arthritis

Tetsuo Kobayashi  1 , Hiromasa Yoshie  2
Affiliations
Review

Host Responses in the Link Between Periodontitis and Rheumatoid Arthritis

Tetsuo Kobayashi et al. Curr Oral Health Rep. 2015.

Abstract

Periodontitis and rheumatoid arthritis (RA) are common chronic inflammatory conditions and share many clinical and pathologic features. There is evidence to suggest that similar profiles of cytokine genotypes and their coding proteins are involved in the pathogenesis of periodontitis and RA. In particular, constitutive overproduction of pro-inflammatory cytokines, including tumor necrosis factor-alpha (TNF-α) and interleukin-6 (IL-6), has been implicated to play a pathologic role in the two inflammatory diseases. Results from studies with animal and human subjects have suggested an improvement of periodontal inflammatory condition after treatment with TNF-α inhibitors. Likewise, IL-6 receptor inhibition therapy has been suggested to have an effect on control of periodontal inflammation in patients with RA. In the present review, we provide an overview of studies showing the pathological role of cytokines in the linkage between periodontitis and RA, and further summarize the current studies assessing the effect of cytokine targeted therapy on periodontal condition.

Keywords: Cytokine; Interluekin-6; Periodontitis; Rheumatoid arthritis; Targeted therapy; Tumor necrosis factor-alpha.

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Conflict of interest statement

Dr. Tetsuo Kobayashi and Dr. Hiromasa Yoshie declare no potential conflicts of interest relevant to this article.

References

    1. Alamanos Y, Voulgari PV, Drosos AA. Incidence and prevalence of rheumatoid arthritis, based on the 1987 American college of rheumatology criteria: a systematic review. Semin Arthritis Rheum. 2006;36(3):182–8. doi: 10.1016/j.semarthrit.2006.08.006. - DOI - PubMed
    1. Greenwald RA, Kirkwood K. Adult periodontitis as a model for rheumatoid arthritis (with emphasis on treatment strategies) J Rheumatol. 1999;26(8):1650–3. - PubMed
    1. Mercado FB, Marshall RI, Klestov AC, Bartold PM. Relationship between rheumatoid arthritis and periodontitis. J Periodontol. 2001;72(6):779–87. doi: 10.1902/jop.2001.72.6.779. - DOI - PubMed
    1. de Pablo P, Chapple ILC, Buckley CD, Dietrich T. Periodontitis in systemic rheumatic diseases. Nat Rev Rheumatol. 2009;5(4):218–24. doi: 10.1038/nrrheum.2009.28. - DOI - PubMed
    1. Bartold PM, Marshall RI, Haynes DR. Periodontitis and rheumatoid arthritis: a review. J Periodontol. 2005;76(11 Suppl):2066–74. doi: 10.1902/jop.2005.76.11-S.2066. - DOI - PubMed

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