A nuclear option that initiates autophagy
- PMID: 25658203
- DOI: 10.1016/j.molcel.2015.01.030
A nuclear option that initiates autophagy
Abstract
In this issue of Molecular Cell, Huang et al. (2015) describe a nuclear pool of LC3 that is deacetylated during starvation, leading to redistribution of this essential autophagy regulator to the cytoplasm, where it can initiate autophagy.
Copyright © 2015 Elsevier Inc. All rights reserved.
Comment on
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Deacetylation of nuclear LC3 drives autophagy initiation under starvation.Mol Cell. 2015 Feb 5;57(3):456-66. doi: 10.1016/j.molcel.2014.12.013. Epub 2015 Jan 15. Mol Cell. 2015. PMID: 25601754
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