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Comment
. 2015 Feb 5;16(2):111-2.
doi: 10.1016/j.stem.2015.01.009.

Do mutational dynamics in stem cells explain the origin of common cancers?

Gerry P Crossan  1 , Juan I Garaycoechea  2 , Ketan J Patel  3
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Do mutational dynamics in stem cells explain the origin of common cancers?

Gerry P Crossan et al. Cell Stem Cell. .
Free article

Abstract

For more than 60 years, we have known that the incidence of certain common human cancers increases with age. Recently in Science, Tomasetti and Vogelstein (2015) refined this model by providing a potential explanation, arguing that early random mutational events within individual stem cells of regenerating organs may underlie this correlation.

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