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Case Reports
. 2016 Feb;13(1):141-2.
doi: 10.1111/iwj.12423. Epub 2015 Feb 9.

Zosteriform pemphigoid after zoster: Wolf's isotopic response

Mehmet S Gurel  1 , Sevil Savas  1 , Fusun Bilgin  1 , Duygu Erdil  1 , Cem Leblebici  2 , Ebru Sarikaya  1
Affiliations
Case Reports

Zosteriform pemphigoid after zoster: Wolf's isotopic response

Mehmet S Gurel et al. Int Wound J. 2016 Feb.

Abstract

The Wolf isotopic response describes the occurrence of a new, unrelated disease that appears at the same location as a previously healed disease. The most common primary skin disorder of this phenomenon is herpes zoster and less frequently, herpes simplex. We report a case of 79-year-old woman who have bullous pemphigoid (BP) with dermatomal distribution that developed at the site of previously healed herpes zoster. Based on clinical, histological and immunofluorescence findings, the patient was diagnosed with localized BP in a site of prior herpes zoster. BP developing at the site of healed herpes zoster is the first reported case. Recognition of this phenomenon is important for correct clinicopathologic diagnosis and may improve our understanding of the underlying pathophysiologic processes.

Keywords: Isotopic response; Pemphigoid; Zoster.

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Figures

Figure 1
Figure 1
Multiple tense vesicles and bullae associated with crusting and erosions on the right breast and the right upper extremity.
Figure 2
Figure 2
Sub‐epidermal blister filled with numerous eosinophils.
See this image and copyright information in PMC

References

    1. Wolf R, Brenner S, Ruocco V, Filioli FG. Isotopic response. Int J Dermatol 1995;34:341–8. - PubMed
    1. Ruocco V, Ruocco E, Ghersetich I, Bianchi B, Lotti T. Isotopic response after herpesvirus infection: an update. J Am Acad Dermatol 2002;46:90–4. - PubMed
    1. Wolf R, Lotti T, Ruocco V. Isomorphic versus isotopic response: data and hypotheses. J Eur Acad Dermatol Venereol 2003;17:123–5. - PubMed
    1. Langan SM, Groves RW, West J. The relationship between neurological disease and bullous pemphigoid: a population‐based case‐control study. J Invest Dermatol 2011;131:631–6. - PubMed
    1. Taghipour K, Chi CC, Vincent A, Groves RW, Venning V, Wojnarowska F. The association of bullous pemphigoid with cerebrovascular disease and dementia: a case‐control study. Arch Dermatol 2010;146:1251–4. - PubMed

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