Review
doi: 10.1016/j.jgyn.2014.12.011.
Epub 2015 Feb 7.
[Methotrexate pharmacology]
[Article in
French]
Affiliations
- PMID: 25661493
- DOI: 10.1016/j.jgyn.2014.12.011
Item in Clipboard
Review
[Methotrexate pharmacology]
[Article in
French]
J Gynecol Obstet Biol Reprod (Paris).
2015 Mar.
Abstract
Methotrexate is a folic acid analog, which is a thymidylate synthetase and dihydrofolate reductase inhibitor. It is used in oncology, dermatology and rheumatology and off labelling in the treatment of ectopic pregnancies. This paper is a review of methotrexate pharmacology with focus on data concerning ectopic pregnancies.
Keywords: Ectopic pregnancy; Grossesse extra-utérine; Methotrexate; Méthotrexate; Pharmacologie; Pharmacology.
Copyright © 2014 Elsevier Masson SAS. All rights reserved.
Similar articles
-
Methotrexate: the pharmacology behind medical treatment for ectopic pregnancy.Clin Obstet Gynecol. 2012 Jun;55(2):433-9. doi: 10.1097/GRF.0b013e3182510a35. Clin Obstet Gynecol. 2012. PMID: 22510625 Review.
-
[How I do… in situ methotrexate injection in the treatment of intramyometrial pregnancy].Gynecol Obstet Fertil. 2016 Jul-Aug;44(7-8):435-6. doi: 10.1016/j.gyobfe.2016.06.011. Epub 2016 Jul 15. Gynecol Obstet Fertil. 2016. PMID: 27426691 French. No abstract available.
-
Fatal methotrexate toxicity in a patient treated for an ectopic pregnancy.Therapie. 2016 Jun;71(3):348-50. doi: 10.1016/j.therap.2015.12.006. Epub 2016 Feb 15. Therapie. 2016. PMID: 27235664 No abstract available.
-
Medical therapy for ectopic pregnancy.Semin Reprod Med. 2007 Mar;25(2):93-8. doi: 10.1055/s-2007-970048. Semin Reprod Med. 2007. PMID: 17377896 Review.
-
Two adolescents with ectopic pregnancies: experience with methotrexate.Pediatr Emerg Care. 2006 Jul;22(7):497-9. doi: 10.1097/01.pec.0000227384.46143.69. Pediatr Emerg Care. 2006. PMID: 16871111
Cited by
-
Methotrexate induces DNA damage and inhibits homologous recombination repair in choriocarcinoma cells.Onco Targets Ther. 2016 Nov 17;9:7115-7122. doi: 10.2147/OTT.S116387. eCollection 2016. Onco Targets Ther. 2016. PMID: 27895503 Free PMC article.
-
An In Vitro Study of the Effects of Methotrexate Loaded Biocomposite Beads on MG63 Osteoblast Cells.Sci Rep. 2025 Jan 17;15(1):2231. doi: 10.1038/s41598-025-85702-y. Sci Rep. 2025. PMID: 39825078 Free PMC article.
-
The Impact of Resveratrol on Oxidative Stress Induced by Methotrexate in Rat Ileum Tissue: Evaluation of Biochemical and Histopathological Features and Analysis of Gene Expression.Med Princ Pract. 2016;25(2):181-6. doi: 10.1159/000442020. Epub 2015 Oct 30. Med Princ Pract. 2016. PMID: 26517535 Free PMC article.
-
Use of methotrexate in the treatment of ectopic pregnancies: a retrospective single center study.Facts Views Vis Obgyn. 2020 Mar 27;11(4):329-335. Facts Views Vis Obgyn. 2020. PMID: 32322829 Free PMC article.
Publication types
MeSH terms
Substances
LinkOut - more resources
Full Text Sources
Medical
