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Comment
. 2015 Feb 7;21(5):1689-90.
doi: 10.3748/wjg.v21.i5.1689.

Unfavorable outcome of antiviral therapy in cytomegalovirus-positive ulcerative colitis may be due to inappropriate study inclusion in meta-analysis

Xiao-Wei Wu  1 , Miao-Fang Yang  1 , Nan Li  1 , Fang-Yu Wang  1
Affiliations
Comment

Unfavorable outcome of antiviral therapy in cytomegalovirus-positive ulcerative colitis may be due to inappropriate study inclusion in meta-analysis

Xiao-Wei Wu et al. World J Gastroenterol. .

Abstract

Some previous articles reported that antiviral treatment was effective to reduce the colectomy rate in ulcerative colitis (UC) patients with cytomegalovirus (CMV) infection. Kopylov et al recently carried out a systematic review and meta-analysis to evaluate the impact of antiviral therapy on CMV-positive UC. The results showed that patients who received antiviral treatment had a higher risk of 30-d colectomy. We found that in this meta-analysis, some studies were inappropriately included, leading to an unfavorable outcome of anti-CMV therapy in UC patients.

Keywords: Antiviral therapy; Colectomy; Cytomegalovirus; Meta-analysis; Ulcerative colitis.

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References

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