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Clinical Trial
. 2015 Oct;40(3):323-30.
doi: 10.1007/s11239-015-1180-z.

Association between micro particle-tissue factor activity, factor VIII activity and recurrent VTE in patients with acute pulmonary embolism

Judith Kooiman  1 , Paul L den Exter, Inci Kilicsoy, Suzanne C Cannegieter, Jeroen Eikenboom, Menno V Huisman, Frederikus A Klok, Henri H Versteeg
Affiliations
Clinical Trial

Association between micro particle-tissue factor activity, factor VIII activity and recurrent VTE in patients with acute pulmonary embolism

Judith Kooiman et al. J Thromb Thrombolysis. 2015 Oct.

Abstract

Studies on the association between microparticle expressing tissue factor (MP-TF) activity, FVIII activity (

Fviii: C) and recurrent VTE yielded inconclusive results. We studied these associations in patients diagnosed with acute pulmonary embolism. Plasma levels of MP-TF and FVIII activity were measured in 277 patients with a first and 72 patients with a recurrent VTE. All patients were categorized based on the quintiles of MP-TF and FVIII activity in those with a single VTE. For both markers, odds ratios (ORs) for recurrent VTE were computed using patients in the lowest quintile as a reference group. No association was observed between MP-TF activity and recurrent VTE, with an OR of 1.4 (95 % CI 0.7-2.9) in the highest quintile of MP-TF activity. Compared with the reference group, patients in the highest quintile of

Fviii: C were at increased risk of recurrent VTE, OR 4.2 (95 % CI 1.4-12.2). MP-TF activity was not associated with recurrent VTE whereas high

Fviii: C levels were associated with a 4-fold increased risk of VTE recurrence. Future prospective studies are necessary to explore the potential of

Fviii: C as a tool for risk stratification, either by itself or in combination with other pro-thrombotic markers.

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Fig. 1
Study design
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