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Comment
. 2015 Mar;135(3):657-659.
doi: 10.1038/jid.2014.449.

Metabolic vulnerability in melanoma: a ME2 (me too) story

Bin Zheng  1 , David E Fisher  2
Affiliations
Comment

Metabolic vulnerability in melanoma: a ME2 (me too) story

Bin Zheng et al. J Invest Dermatol. 2015 Mar.

Abstract

Metabolic reprograming is a hallmark of cancer and might represent an Achilles' heel in cancer cells. The study by Chang et al. in this issue highlights a critical role of mitochondrial malic enzyme 2 (ME2) in melanoma progression. Targeting ME2 could be an effective approach to inhibit melanoma cell proliferation and tumor growth.

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References

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