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Review
. 2015 Mar;12(3):137-44.
doi: 10.1038/nrurol.2015.13. Epub 2015 Feb 10.

Are androgen receptor variants a substitute for the full-length receptor?

Ji Lu  1 , Travis Van der Steen  2 , Donald J Tindall  3
Affiliations
Review

Are androgen receptor variants a substitute for the full-length receptor?

Ji Lu et al. Nat Rev Urol. 2015 Mar.

Abstract

Androgen receptor splice variants (AR-Vs)--which are expressed in castration-resistant prostate cancer (CRPC) cell lines and clinical samples--lack the C-terminal ligand-binding domain and are constitutively active. AR-Vs are, therefore, resistant to traditional androgen deprivation therapy (ADT). AR-Vs are induced by several mechanisms, including ADT, and might contribute to the progression of CRPC and resistance to ADT. AR-Vs could represent a novel therapeutic target for prostate cancer, especially in CRPC.

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