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Review
. 2015 Mar;44(1):31-8.
doi: 10.1016/j.gtc.2014.11.004. Epub 2014 Dec 19.

Histologic changes in diabetic gastroparesis

Gianrico Farrugia  1
Affiliations
Review

Histologic changes in diabetic gastroparesis

Gianrico Farrugia. Gastroenterol Clin North Am. 2015 Mar.

Abstract

The cellular abnormalities that lead to diabetic gastroparesis are increasingly being understood. Several key cell types are affected by diabetes, leading to gastroparesis. These changes include abnormalities in the extrinsic innervation to the stomach, loss of key neurotransmitters at the level of the enteric nervous system, smooth muscle abnormalities, loss of interstitial cells of Cajal, and changes in the macrophage population resident in the muscle wall. This article reviews the current understanding with a focus on data from human studies when available.

Keywords: Enteric nerves; Gastric emptying; Interstitial cells of Cajal; Macrophages; Smooth muscle; Vagus.

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References

    1. Duchen LW, Anjorin A, Watkins PJ, et al. Pathology of autonomic neuropathy in diabetes mellitus. Ann Intern Med. 1980;92:301–303. - PubMed
    1. Buysschaert M, Donckier J, Dive A, et al. Gastric acid and pancreatic polypeptide responses to sham feeding are impaired in diabetic subjects with autonomic neuropathy. Diabetes. 1985;34:1181–1185. - PubMed
    1. Schwartz TW. Pancreatic polypeptide: a hormone under vagal control. Gastroenterology. 1983;85:1411–1425. - PubMed
    1. Iwasaki H, Kajimura M, Osawa S, et al. A deficiency of gastric interstitial cells of Cajal accompanied by decreased expression of neuronal nitric oxide synthase and substance P in patients with type 2 diabetes mellitus. J Gastroenterol. 2006;41:1076–1087. - PubMed
    1. Guy RJ, Dawson JL, Garrett JR, et al. Diabetic gastroparesis from autonomic neuropathy: surgical considerations and changes in vagus nerve morphology. J Neurol Neurosurg Psychiatry. 1984;47:686–691. - PMC - PubMed

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