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. 2015 Mar 11;15(3):1526-34.
doi: 10.1021/acs.nanolett.5b00315. Epub 2015 Feb 12.

Nanoscale control of surface immobilized BMP-2: toward a quantitative assessment of BMP-mediated signaling events

Elisabeth H Schwab  1 , Theresa L M Pohl, Tamás Haraszti, Gerburg K Schwaerzer, Christian Hiepen, Joachim P Spatz, Petra Knaus, Elisabetta A Cavalcanti-Adam
Affiliations

Nanoscale control of surface immobilized BMP-2: toward a quantitative assessment of BMP-mediated signaling events

Elisabeth H Schwab et al. Nano Lett. .

Abstract

In this work we determine the impact of surface density of immobilized BMP-2 on intracellular signal transduction. We use block copolymer micellar nanolithography to fabricate substrates with precisely spaced and tunable gold nanoparticle arrays carrying single BMP-2 molecules. We found that the immobilized growth factor triggers prolonged and elevated Smad signaling pathway activation compared to the same amount of soluble protein. This approach is suitable for achieving controlled and sustained local delivery of BMP-2 and other growth factors.

Keywords: BCMN; BMP-2; cell signaling; covalent immobilization; gold nanostructures.

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