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. 1989 Jun 10;1(8650):1292-5.
doi: 10.1016/s0140-6736(89)92687-1.

Linkage between immunoglobulin E responses underlying asthma and rhinitis and chromosome 11q

W O Cookson  1 , P A Sharp, J A Faux, J M Hopkin
Affiliations

Linkage between immunoglobulin E responses underlying asthma and rhinitis and chromosome 11q

W O Cookson et al. Lancet. .

Abstract

Family studies of IgE responses to common inhaled antigens have suggested dominant inheritance of atopy. Molecular genetic linkage analysis was used to confirm this proposal. In seven families the transmission of atopy was linked, with a maximum lod score of 5.58, to a DNA polymorphism defined by p lambda MS.51, which confirms dominant inheritance and assigns the gene locus to chromosome 11.

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