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Editorial
. 2015;14(6):787-8.
doi: 10.1080/15384101.2015.1010963.

Myheart hits the core of chromatin

Pei Han  1 , Ching-Pin Chang
Affiliations
Editorial

Myheart hits the core of chromatin

Pei Han et al. Cell Cycle. 2015.
No abstract available

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Figures

Figure 1.
Figure 1.
Brg1 (orange) recognizes and binds to the chromatinized/nucleosomal DNA, which wraps around the histone core (left panel). The long noncoding RNA Myheart (emerald) binds to Brg1 and sequesters it from its genomic DNA target locus (right panel).
See this image and copyright information in PMC

Comment on

  • A long noncoding RNA protects the heart from pathological hypertrophy.
    Han P, Li W, Lin CH, Yang J, Shang C, Nuernberg ST, Jin KK, Xu W, Lin CY, Lin CJ, Xiong Y, Chien H, Zhou B, Ashley E, Bernstein D, Chen PS, Chen HV, Quertermous T, Chang CP. Han P, et al. Nature. 2014 Oct 2;514(7520):102-106. doi: 10.1038/nature13596. Epub 2014 Aug 10. Nature. 2014. PMID: 25119045 Free PMC article.

References

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    1. Han P, et al. Nature 2014; 514:102-6; PMID:25119045; http://dx.doi.org/ 10.1038/nature13596 - DOI - PMC - PubMed
    1. Rinn JL, et al. Annu Rev Biochem 2012; 81:145-66; PMID:22663078; http://dx.doi.org/ 10.1146/annurev-biochem-051410-092902 - DOI - PMC - PubMed
    1. Hang CT, et al. Nature 2010; 466:62-7; PMID:20596014; http://dx.doi.org/ 10.1038/nature09130 - DOI - PMC - PubMed
    1. Linder P, et al. Nat Rev Mol Cell Biol 2011; 12:505-16. - PubMed

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