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. 1989 May 25;339(6222):280-6.
doi: 10.1038/339280a0.

The role of cyclin synthesis and degradation in the control of maturation promoting factor activity

A W Murray  1 , M J Solomon, M W Kirschner
Affiliations

The role of cyclin synthesis and degradation in the control of maturation promoting factor activity

A W Murray et al. Nature. .

Abstract

We show that cyclin plays a pivotal role in the control of mitosis. A proteolysis-resistant mutant of cyclin prevents the inactivation of maturation promoting factor and the exit from mitosis both in vivo and in vitro. We have used a fractionated extract to study the activation of MPF by added cyclin protein.

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